Technology Process of (2R,3R)-2-(t-butoxycarbonylamino)-3-hydroxy-3-(4-hydroxycyclohexyl)propanoic acid
There total 3 articles about (2R,3R)-2-(t-butoxycarbonylamino)-3-hydroxy-3-(4-hydroxycyclohexyl)propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C9H17NO4;
With
lithium hydroxide;
In
ethanol;
for 2h;
di-tert-butyl dicarbonate;
In
ethanol;
for 2h;
With
potassium hydrogensulfate;
In
ethanol; water;
pH=3 - 4;
DOI:10.1016/j.bmc.2011.05.022
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tris(ethoxy)monochloro titanium; triethylamine / dichloromethane / 5 h / 0 °C
1.2: Cooling
2.1: hydrogenchloride / tetrahydrofuran; water
3.1: lithium hydroxide / ethanol / 2 h
3.2: 2 h
3.3: pH 3 - 4
With
hydrogenchloride; tris(ethoxy)monochloro titanium; triethylamine; lithium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water;
1.1: Aldol condensation;
DOI:10.1016/j.bmc.2011.05.022
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride / tetrahydrofuran; water
2.1: lithium hydroxide / ethanol / 2 h
2.2: 2 h
2.3: pH 3 - 4
With
hydrogenchloride; lithium hydroxide;
In
tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmc.2011.05.022
