C₂₈H₃₂FN₃O₅

Base Information

• Chemical Name: C₂₈H₃₂FN₃O₅
• CAS No.: 1367126-95-1
• Molecular Formula: C₂₈H₃₂FN₃O₅
• Molecular Weight: 509.578
• Mol file: 1367126-95-1.mol

Synonyms:C₂₈H₃₂FN₃O₅

Chemical Property of C₂₈H₃₂FN₃O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₃₂FN₃O₅

There total 11 articles about C₂₈H₃₂FN₃O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C28H30FN3O3 (1367126-93-9) → C28H32FN3O5 (1367126-95-1)

Guidance literature:

With AD-mix α; In water; tert-butyl alcohol; at 0 - 20 ℃; for 48h;

Reference yield:

4-Fluorophenol (371-41-5) → C28H32FN3O5 (1367126-95-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere

3.1: sulfuric acid / 1,2-dimethoxyethane; water

3.2: 0.83 h / 0 - 5 °C

3.3: 0.5 h / 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

4.2: 18 h / 90 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 70 °C

6.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 5 h / 80 °C

7.1: AD-mix α / water; tert-butyl alcohol / 48 h / 0 - 20 °C

With AD-mix α; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → C28H32FN3O5 (1367126-95-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere

3.1: sulfuric acid / 1,2-dimethoxyethane; water

3.2: 0.83 h / 0 - 5 °C

3.3: 0.5 h / 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

4.2: 18 h / 90 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 70 °C

6.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 5 h / 80 °C

7.1: AD-mix α / water; tert-butyl alcohol / 48 h / 0 - 20 °C

With AD-mix α; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

4-Fluorophenol

4-Fluoronitrobenzene

4-(4-fluorophenoxy)aniline

4-(4-fluorophenoxy)-1-nitrobenzene