3-(3-chloro-4-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

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Chemical Name:3-(3-chloro-4-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide
CAS No.:1309606-05-0
Molecular Formula:C₂₄H₂₈ClN₅O₂
Molecular Weight:453.972
Hs Code.:

Synonyms:3-(3-chloro-4-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

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Chemical Property of 3-(3-chloro-4-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

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Technology Process of 3-(3-chloro-4-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

There total 8 articles about 3-(3-chloro-4-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(3-chloro-4-methoxyphenyl)-2-(pyridin-4-yl)ethanone

: 1309606-05-0
3-(3-chloro-4-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 18 h / 20 °C

1.2: 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

2.2: 1 h / 20 °C

With triethylamine; In tetrahydrofuran;
DOI:10.1111/cbdd.12186

Reference yield:

: 51-44-5
3,4-dichlorbenzoic acid

: 1309606-05-0
3-(3-chloro-4-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N,N,N,N,N-hexamethylphosphoric triamide / 15 h / 115 - 120 °C

2.1: acetyl chloride / 15 h / 0 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -25 - 20 °C

4.1: 18 h / 20 °C

4.2: 20 °C

5.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

5.2: 1 h / 20 °C

With triethylamine; acetyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1111/cbdd.12186

Reference yield:

: 37908-96-6
3-chloro-4-methoxy benzoic acid

: 1309606-05-0
3-(3-chloro-4-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetyl chloride / 15 h / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -25 - 20 °C

3.1: 18 h / 20 °C

3.2: 20 °C

4.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.2: 1 h / 20 °C

With triethylamine; acetyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1111/cbdd.12186