1-(2-methyl-5-nitrophenyl)-6-(1,3-thiazol-5-yl)-1H-imidazo[1,2-b]pyrazole

Base Information

Chemical Name:1-(2-methyl-5-nitrophenyl)-6-(1,3-thiazol-5-yl)-1H-imidazo[1,2-b]pyrazole
CAS No.:1448318-81-7
Molecular Formula:C₁₅H₁₁N₅O₂S
Molecular Weight:325.351
Hs Code.:

Synonyms:1-(2-methyl-5-nitrophenyl)-6-(1,3-thiazol-5-yl)-1H-imidazo[1,2-b]pyrazole

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Chemical Property of 1-(2-methyl-5-nitrophenyl)-6-(1,3-thiazol-5-yl)-1H-imidazo[1,2-b]pyrazole

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Technology Process of 1-(2-methyl-5-nitrophenyl)-6-(1,3-thiazol-5-yl)-1H-imidazo[1,2-b]pyrazole

There total 3 articles about 1-(2-methyl-5-nitrophenyl)-6-(1,3-thiazol-5-yl)-1H-imidazo[1,2-b]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1448318-80-6
1-(2,2-diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-3-(1,3-thiazol-5-yl)-1H-pyrazole-5-amine

: 1448318-81-7
1-(2-methyl-5-nitrophenyl)-6-(1,3-thiazol-5-yl)-1H-imidazo[1,2-b]pyrazole

Guidance literature:: With sulfuric acid; In ethanol; at 125 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: sodium 2-cyano-1-(1,3-thiazol-5-yl)ethenolate

: 1448318-81-7
1-(2-methyl-5-nitrophenyl)-6-(1,3-thiazol-5-yl)-1H-imidazo[1,2-b]pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; hydrogenchloride / ethanol; water / 2 h / Reflux

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

3: sulfuric acid / ethanol / 0.33 h / 125 °C / Microwave irradiation

With hydrogenchloride; sulfuric acid; palladium diacetate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water;

Reference yield:

: 1448318-53-3
1-(2,2-diethoxyethyl)-3-(1,3-thiazol-5-yl)-1H-pyrazole-5-amine

: 1448318-81-7
1-(2-methyl-5-nitrophenyl)-6-(1,3-thiazol-5-yl)-1H-imidazo[1,2-b]pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

2: sulfuric acid / ethanol / 0.33 h / 125 °C / Microwave irradiation

With sulfuric acid; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol;