TETRAHYDRODEOXYCORTICOSTERONE

Base Information

• Chemical Name: TETRAHYDRODEOXYCORTICOSTERONE
• CAS No.: 567-03-3
• Molecular Formula: C21H34 O3
• Molecular Weight: 334.499
• Mol file: 567-03-3.mol

Synonyms:5b-Pregnan-20-one, 3a,21-dihydroxy- (8CI);Corticosterone, 11-deoxytetrahydro- (6CI); Corticosterone, deoxytetrahydro- (7CI);21-Hydroxypregnanolone; 3a,21-Dihydroxy-5b-pregnan-20-one; 3a,5b-Tetrahydrodeoxycorticosterone; 5b-Pregnan-3a,21-diol-20-one; 5b-Pregnane-3a,21-diol-20-one;Deoxytetrahydrocorticosterone; Tetrahydro DOC;Tetrahydro-11-deoxycorticosterone; Tetrahydrodeoxycorticosterone

Chemical Property of TETRAHYDRODEOXYCORTICOSTERONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 470.3°Cat760mmHg
• PKA: 12.98±0.10(Predicted)
• Flash Point: 252.3°C
• PSA: 57.53000
• Density: 1.115g/cm³
• LogP: 3.56760
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Tetrahydro11-Deoxycorticosterone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tetrahydro 11-Deoxycorticosterone is a metabolite of 11-Deoxycorticosterone (DOC) (D232590).

Technology Process of TETRAHYDRODEOXYCORTICOSTERONE

There total 28 articles about TETRAHYDRODEOXYCORTICOSTERONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(3β,5α)-21-bromo-3-hydroxypregnan-20-one (51296-50-5,95341-20-1) → (3β,5α)-3,21-dihydroxypregnan-20-one (567-02-2,567-03-3,800-10-2,33995-21-0,51548-31-3,108450-73-3,567-01-1)

Guidance literature:

With water; sodium hydroxide; for 0.5h;

DOI:10.1021/jm300317k

Reference yield: 72.0%

3α,21-diacetoxy-5β-pregnan-20-one (1693-62-5) → tetrahydrodeoxycorticosterone (567-03-3)

Guidance literature:

With sulfuric acid; In ethanol; for 24h; Heating;

DOI:10.1515/znb-1984-1125

Reference yield: 44.0%

deoxycorticosterone acetate (56-47-3) → (3β,5α)-3,21-dihydroxypregnan-20-one (567-02-2,567-03-3,800-10-2,33995-21-0,51548-31-3,108450-73-3,567-01-1) + 5α-pregnan-21-ol-3,20-dione (298-36-2)

Guidance literature:

In ethanol; at 24 - 26 ℃; for 96h; Penicillium decumbens ATCC 10436, potato dextrose broth;

DOI:10.1016/0039-128X(95)00071-W

upstream raw materials:

21-hydroxy-5β-pregnane-3,20-dione

21-Hydroxyprogesterone

3α,21-diacetoxy-5β-pregnan-20-one

21-hydroxy-20-oxo-5β-pregnan-3α-yl β-D-glucopyranosiduronic acid

Downstream raw materials:

epipregnanolone acetate

3α-tosyloxy-5β-androstan-17β-carboxylic acid methyl ester

5β-pregnan-3α,21-diol-20-one, 17,21,21-d3

Refernces

• 1、 Hamilton, Niall M.,Dawson, Martin,Fairweather, Emma E.,Hamilton, Nicola S.,Hitchin, James R.,James, Dominic I.,Jones, Stuart D.,Jordan, Allan M.,Lyons, Amanda J.,Small, Helen F.,Thomson, Graeme J.,Waddell, Ian D.,Ogilvie, Donald J.. "Novel steroid inhibitors of glucose 6-phosphate dehydrogenase". . p. 4431 - 4445. Retrieved 2012/09/11.
• 2、 Holland, Herbert L.. "Biotransformation of corticosteroids by Penicillium decumbens ATCC 10436". . p. 646 - 649. Retrieved 2007/10/02.