(2S,5S)-1,2-dibenzyl-5-((tert-butyldiphenylsilyloxy)methyl)-2-ethylpyrrolidine

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Chemical Name:(2S,5S)-1,2-dibenzyl-5-((tert-butyldiphenylsilyloxy)methyl)-2-ethylpyrrolidine
CAS No.:1228469-11-1
Molecular Formula:C₃₇H₄₅NOSi
Molecular Weight:547.856
Hs Code.:

Synonyms:(2S,5S)-1,2-dibenzyl-5-((tert-butyldiphenylsilyloxy)methyl)-2-ethylpyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,5S)-1,2-dibenzyl-5-((tert-butyldiphenylsilyloxy)methyl)-2-ethylpyrrolidine

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Technology Process of (2S,5S)-1,2-dibenzyl-5-((tert-butyldiphenylsilyloxy)methyl)-2-ethylpyrrolidine

There total 1 articles about (2S,5S)-1,2-dibenzyl-5-((tert-butyldiphenylsilyloxy)methyl)-2-ethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 925-90-6
ethylmagnesium bromide

: 138871-54-2
(S)-5-(tert-butyldiphenylsilyloxymethyl)-1-(phenylmethyl)-2-pyrrolidinone

: 6921-34-2
benzylmagnesium chloride

: 1228469-11-1
(2S,5S)-1,2-dibenzyl-5-((tert-butyldiphenylsilyloxy)methyl)-2-ethylpyrrolidine

: (2R,5S)-1,2-dibenzyl-5-((tert-butyldiphenylsilyloxy)methyl)-2-ethylpyrrolidine

Guidance literature:: (S)-5-(tert-butyldiphenylsilyloxymethyl)-1-(phenylmethyl)-2-pyrrolidinone; With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 ℃; for 0.75h; Inert atmosphere;

ethylmagnesium bromide; In dichloromethane; at -78 - 20 ℃; for 1h; Inert atmosphere;

benzylmagnesium chloride; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/chem.201302096