Technology Process of (+/-)-2-(2-(N,N'-bis(t-butoxycarbonyl)hydrazino)-3-phenylpropanoyl)-2-ethyl-1,3-dithiane
There total 2 articles about (+/-)-2-(2-(N,N'-bis(t-butoxycarbonyl)hydrazino)-3-phenylpropanoyl)-2-ethyl-1,3-dithiane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -20 °C
1.2: 74 percent / tetrahydrofuran; hexane / 1 h / -20 - 20 °C
2.1: 98 percent / TFAA; DMSO; triethylamine / CH2Cl2 / 2.5 h / -78 - 20 °C
3.1: lithium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C
3.2: 93 percent / tetrahydrofuran; CH2Cl2 / -78 - 20 °C
With
n-butyllithium; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane; dichloromethane;
1.1: Metallation / 1.2: Addition / 2.1: Swern oxidation / 3.1: Metallation / 3.2: Addition;
DOI:10.1016/S0040-4020(00)00923-6
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 98 percent / TFAA; DMSO; triethylamine / CH2Cl2 / 2.5 h / -78 - 20 °C
2.1: lithium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C
2.2: 93 percent / tetrahydrofuran; CH2Cl2 / -78 - 20 °C
With
dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane;
1.1: Swern oxidation / 2.1: Metallation / 2.2: Addition;
DOI:10.1016/S0040-4020(00)00923-6
