(2S)-5'-<(2-Benzyloxycarbonyl-2-hydroxyimino)acetyl>-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalanin-methylester

Base Information

Chemical Name:(2S)-5'-<(2-Benzyloxycarbonyl-2-hydroxyimino)acetyl>-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalanin-methylester
CAS No.:91421-16-8
Molecular Formula:C₂₇H₃₂N₂O₉
Molecular Weight:528.559
Hs Code.:

Synonyms:(2S)-5'-<(2-Benzyloxycarbonyl-2-hydroxyimino)acetyl>-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalanin-methylester

Suppliers and Price of (2S)-5'-<(2-Benzyloxycarbonyl-2-hydroxyimino)acetyl>-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalanin-methylester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-5'-<(2-Benzyloxycarbonyl-2-hydroxyimino)acetyl>-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalanin-methylester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-5'-<(2-Benzyloxycarbonyl-2-hydroxyimino)acetyl>-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalanin-methylester

There total 9 articles about (2S)-5'-<(2-Benzyloxycarbonyl-2-hydroxyimino)acetyl>-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalanin-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 91465-29-1
(2S)-5'-<(Benzyloxycarbonyl)acetyl>-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalanin-methylester

: 91421-16-8
(2S)-5'-<(2-Benzyloxycarbonyl-2-hydroxyimino)acetyl>-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalanin-methylester

Guidance literature:: With sodium nitrite; In water; acetic acid; at 0 ℃; for 2h;
DOI:10.1002/jlac.198419840616

Reference yield:

: 91420-99-4
3-formyl-4-methoxy-benzoic acid

: 91421-16-8
(2S)-5'-<(2-Benzyloxycarbonyl-2-hydroxyimino)acetyl>-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalanin-methylester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) 1N NaOH / 2.) DMF, 4 h, 70 deg C

2: 72 percent / t-BuOK / CH₂Cl₂ / 1.) <= -60 deg C, 2.) room temperature, 3 h

3: 78 percent / K₂CO₃ / dimethylformamide / 72 h

4: 97 percent / H₂ / >-tetrafluoroborate / ethanol / 18 h / 40 °C / 2206.5 Torr

5: 82 percent / H₂ / 5percent Pd/C / methanol / 2 h / 2206.5 Torr / Ambient temperature

6: 1.) N,N'-carbonyldiimidazole / 1.)THF, 30 min, room temperature 2.) 5h, 50 deg C

7: 92 percent / NaNO₂ / acetic acid; H₂O / 2 h / 0 °C

With sodium hydroxide; potassium tert-butylate; hydrogen; potassium carbonate; 1,1'-carbonyldiimidazole; sodium nitrite; palladium on activated charcoal; >-tetrafluoroborate; In methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/jlac.198419840616

Reference yield:

: 121056-95-9,89524-98-1
trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate

: 91421-16-8
(2S)-5'-<(2-Benzyloxycarbonyl-2-hydroxyimino)acetyl>-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalanin-methylester

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / t-BuOK / CH₂Cl₂ / 1.) <= -60 deg C, 2.) room temperature, 3 h

2: 78 percent / K₂CO₃ / dimethylformamide / 72 h

3: 97 percent / H₂ / >-tetrafluoroborate / ethanol / 18 h / 40 °C / 2206.5 Torr

4: 82 percent / H₂ / 5percent Pd/C / methanol / 2 h / 2206.5 Torr / Ambient temperature

5: 1.) N,N'-carbonyldiimidazole / 1.)THF, 30 min, room temperature 2.) 5h, 50 deg C

6: 92 percent / NaNO₂ / acetic acid; H₂O / 2 h / 0 °C

With potassium tert-butylate; hydrogen; potassium carbonate; 1,1'-carbonyldiimidazole; sodium nitrite; palladium on activated charcoal; >-tetrafluoroborate; In methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/jlac.198419840616