(25R)-3α,26-dihydroxy-5α-cholestan-15α-yl 2-(acetylamino)-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranoside

Base Information

Chemical Name:(25R)-3α,26-dihydroxy-5α-cholestan-15α-yl 2-(acetylamino)-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranoside
CAS No.:872465-38-8
Molecular Formula:C₅₆H₇₉NO₈
Molecular Weight:894.245
Hs Code.:

Synonyms:(25R)-3α,26-dihydroxy-5α-cholestan-15α-yl 2-(acetylamino)-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranoside

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Chemical Property of (25R)-3α,26-dihydroxy-5α-cholestan-15α-yl 2-(acetylamino)-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranoside

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Technology Process of (25R)-3α,26-dihydroxy-5α-cholestan-15α-yl 2-(acetylamino)-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranoside

There total 10 articles about (25R)-3α,26-dihydroxy-5α-cholestan-15α-yl 2-(acetylamino)-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 872465-37-7
(25R)-15α-(2-acetylamino-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyloxy)-3α-benzoyloxy-5α-cholestan-26-yl benzoate

: 872465-38-8
(25R)-3α,26-dihydroxy-5α-cholestan-15α-yl 2-(acetylamino)-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranoside

Guidance literature:: With potassium hydroxide; In methanol; dichloromethane; for 12h; Heating;
DOI:10.1021/jo051733a

Reference yield:

: 872465-33-3
(25R)-5α-cholest-16-ene-3α,26-diol 3,26-dibenzoate

: 872465-38-8
(25R)-3α,26-dihydroxy-5α-cholestan-15α-yl 2-(acetylamino)-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / chromium trioxide; 3,5-dimethylpyrazole / CH₂Cl₂ / 5 h / -20 °C

2: 98 percent / NaBH₄; cerium trichloride / tetrahydrofuran; methanol / 2 h / 20 °C

3: 98 percent / H₂ / Pd(OH)2/C / ethyl acetate / 3 h

4: 72 percent / AgClO₄; SnCl₂ / CH₂Cl₂ / 16 h / 0 °C

5: 90 percent / KOH / methanol; CH₂Cl₂ / 12 h / Heating

With 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; potassium hydroxide; sodium tetrahydroborate; cerium(III) chloride; hydrogen; silver perchlorate; tin(ll) chloride; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 2: Luche reduction;
DOI:10.1021/jo051733a

Reference yield:

: 872465-34-4
(25R)-3α,26-dihydroxy-5α-cholest-16-en-15-one 3,26-dibenzoate

: 872465-38-8
(25R)-3α,26-dihydroxy-5α-cholestan-15α-yl 2-(acetylamino)-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / NaBH₄; cerium trichloride / tetrahydrofuran; methanol / 2 h / 20 °C

2: 98 percent / H₂ / Pd(OH)2/C / ethyl acetate / 3 h

3: 72 percent / AgClO₄; SnCl₂ / CH₂Cl₂ / 16 h / 0 °C

4: 90 percent / KOH / methanol; CH₂Cl₂ / 12 h / Heating

With potassium hydroxide; sodium tetrahydroborate; cerium(III) chloride; hydrogen; silver perchlorate; tin(ll) chloride; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 1: Luche reduction;
DOI:10.1021/jo051733a