13-Cyclohexyl-N-((dimethylamino)sulfonyl)-6-(((2R,6S)-2,6-dimethyl-4-morpholinyl)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-10-carboxamide

Base Information

Chemical Name:13-Cyclohexyl-N-((dimethylamino)sulfonyl)-6-(((2R,6S)-2,6-dimethyl-4-morpholinyl)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-10-carboxamide
CAS No.:1049797-09-2
Molecular Formula:C₃₃H₄₁N₅O₆S
Molecular Weight:635.784
Hs Code.:

13-Cyclohexyl-N-((dimethylamino)sulfonyl)-6-(((2R,6S)-2,6-dimethyl-4-morpholinyl)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-10-carboxamide

Synonyms:13-Cyclohexyl-N-((dimethylamino)sulfonyl)-6-(((2R,6S)-2,6-dimethyl-4-morpholinyl)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-10-carboxamide

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Chemical Property of 13-Cyclohexyl-N-((dimethylamino)sulfonyl)-6-(((2R,6S)-2,6-dimethyl-4-morpholinyl)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-10-carboxamide

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Technology Process of 13-Cyclohexyl-N-((dimethylamino)sulfonyl)-6-(((2R,6S)-2,6-dimethyl-4-morpholinyl)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-10-carboxamide

There total 12 articles about 13-Cyclohexyl-N-((dimethylamino)sulfonyl)-6-(((2R,6S)-2,6-dimethyl-4-morpholinyl)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-10-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1049797-07-0
13-Cyclohexyl-10-((((dimethylamino)sulfonyl)amino)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-6-carboxylic acid

: 141-91-3,6485-45-6,6485-55-8
cis-2,6-dimethylmorpholine

: 1049797-09-2
13-Cyclohexyl-N-((dimethylamino)sulfonyl)-6-(((2R,6S)-2,6-dimethyl-4-morpholinyl)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-10-carboxamide

Guidance literature:: With HATU; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 494799-64-3
3-cyclohexenyl-1H-pyrrolo[2,3-b]pyridine

: 1049797-09-2
13-Cyclohexyl-N-((dimethylamino)sulfonyl)-6-(((2R,6S)-2,6-dimethyl-4-morpholinyl)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-10-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; ethanol / 144 h

2.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 4 h / Heating / reflux

3.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dimethoxyethane / 1 h / 20 °C

3.2: 1.17 h / 20 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

4.2: 2 h / 50 °C

4.3: 2.5 h / 20 °C

5.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / palladium diacetate / toluene / 2 h / Heating / reflux

6.1: ammonium chloride; zinc / tetrahydrofuran; water / 0.92 h

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / Heating / reflux

8.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 65 °C

9.1: sodium hydroxide; water / tetrahydrofuran / 0.17 h / Heating / reflux

9.2: 20 °C

10.1: HATU / dichloromethane / 1 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium hydroxide; potassium phosphate; pyridinium hydrobromide perbromide; tetrabutyl ammonium fluoride; water; hydrogen; ammonium chloride; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; HATU; zinc; lithium diisopropyl amide; palladium diacetate; 20% Pd(OH)2 on carbon; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 5.1: Suzuki Coupling / 8.1: Horner Emmons reaction;

Reference yield:

: 494799-65-4
3-cyclohexyl-1H-pyrrolo[2,3-b]pyridine

: 1049797-09-2
13-Cyclohexyl-N-((dimethylamino)sulfonyl)-6-(((2R,6S)-2,6-dimethyl-4-morpholinyl)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-10-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 4 h / Heating / reflux

2.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dimethoxyethane / 1 h / 20 °C

2.2: 1.17 h / 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

3.2: 2 h / 50 °C

3.3: 2.5 h / 20 °C

4.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / palladium diacetate / toluene / 2 h / Heating / reflux

5.1: ammonium chloride; zinc / tetrahydrofuran; water / 0.92 h

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / Heating / reflux

7.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 65 °C

8.1: sodium hydroxide; water / tetrahydrofuran / 0.17 h / Heating / reflux

8.2: 20 °C

9.1: HATU / dichloromethane / 1 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium hydroxide; potassium phosphate; pyridinium hydrobromide perbromide; tetrabutyl ammonium fluoride; water; ammonium chloride; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; HATU; zinc; lithium diisopropyl amide; palladium diacetate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 4.1: Suzuki Coupling / 7.1: Horner Emmons reaction;