(3'S,5'R)-5'-Acetoxymethyl-1-benzyl-4-oxo-1,2,3,4,3',4',5',6'-octahydro-2'H-[2,3']bipyridinyl-1'-carboxylic acid benzyl ester

Base Information Edit

Chemical Name:(3'S,5'R)-5'-Acetoxymethyl-1-benzyl-4-oxo-1,2,3,4,3',4',5',6'-octahydro-2'H-[2,3']bipyridinyl-1'-carboxylic acid benzyl ester
CAS No.:478239-25-7
Molecular Formula:C₂₈H₃₂N₂O₅
Molecular Weight:476.572
Hs Code.:
Mol file:478239-25-7.mol

Synonyms:(3'S,5'R)-5'-Acetoxymethyl-1-benzyl-4-oxo-1,2,3,4,3',4',5',6'-octahydro-2'H-[2,3']bipyridinyl-1'-carboxylic acid benzyl ester

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Chemical Property of (3'S,5'R)-5'-Acetoxymethyl-1-benzyl-4-oxo-1,2,3,4,3',4',5',6'-octahydro-2'H-[2,3']bipyridinyl-1'-carboxylic acid benzyl ester Edit

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Technology Process of (3'S,5'R)-5'-Acetoxymethyl-1-benzyl-4-oxo-1,2,3,4,3',4',5',6'-octahydro-2'H-[2,3']bipyridinyl-1'-carboxylic acid benzyl ester

There total 2 articles about (3'S,5'R)-5'-Acetoxymethyl-1-benzyl-4-oxo-1,2,3,4,3',4',5',6'-octahydro-2'H-[2,3']bipyridinyl-1'-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 54125-02-9
danishefsky's diene

: 100-46-9
benzylamine

: 206554-39-4
(3R,5S)-3-Acetoxymethyl-5-formyl-piperidine-1-carboxylic acid benzyl ester

: 478239-25-7
(3'S,5'R)-5'-Acetoxymethyl-1-benzyl-4-oxo-1,2,3,4,3',4',5',6'-octahydro-2'H-[2,3']bipyridinyl-1'-carboxylic acid benzyl ester

Guidance literature:: With magnesium sulfate; scandium tris(trifluoromethanesulfonate); In acetonitrile; at 20 ℃;
DOI:10.1016/S0040-4039(02)01671-4

Reference yield:

: 206761-40-2
(3R,5S)-3-Acetoxymethyl-5-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester

: 478239-25-7
(3'S,5'R)-5'-Acetoxymethyl-1-benzyl-4-oxo-1,2,3,4,3',4',5',6'-octahydro-2'H-[2,3']bipyridinyl-1'-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / DMSO; (COCl)2 / triethylamine

2: 89 percent / MgSO₄ / Sc(OTf)3 / acetonitrile / 20 °C

With oxalyl dichloride; magnesium sulfate; dimethyl sulfoxide; scandium tris(trifluoromethanesulfonate); In triethylamine; acetonitrile; 2: imino Diels-Alder reaction;
DOI:10.1016/S0040-4039(02)01671-4