2-Amino-2-methyl-1-propanol hydrochloride

Base Information

• Chemical Name: 2-Amino-2-methyl-1-propanol hydrochloride
• CAS No.: 3207-12-3
• Molecular Formula: C4H11 N O . Cl H
• Molecular Weight: 125.598
• Hs Code.: 2922 19 00
• European Community (EC) Number: 221-713-5
• DSSTox Substance ID: DTXSID2062905
• Mol file: 3207-12-3.mol

Synonyms:2-amino-2-methyl-1-propanol;2-amino-2-methyl-1-propanol hydrochloride;2-amino-2-methyl-1-propanol mesylate;2-amino-2-methyl-1-propanol nitrate salt;2-amino-2-methyl-1-propanol tosylate;2-amino-2-methylpropanol;aminomethyl propanol

Chemical Property of 2-Amino-2-methyl-1-propanol hydrochloride

Chemical Property:

• Melting Point: 204-206 °C
• Boiling Point: 167.2oC at 760 mmHg
• PKA: 9.7(at 25℃)
• Flash Point: 67.2oC
• PSA: 46.25000
• LogP: 1.21830
• Storage Temp.: Store at RT.
• Solubility.: H2O: 0.5 g/mL, clear, colorless
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 125.0607417
• Heavy Atom Count: 7
• Complexity: 42.8

Purity/Quality:

99.9% ^*data from raw suppliers

2-Amino-2-methyl-1-propanol hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(CO)N.Cl

Technology Process of 2-Amino-2-methyl-1-propanol hydrochloride

There total 5 articles about 2-Amino-2-methyl-1-propanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

N-(1-cyano-1-methyl-ethyl)formamide (58004-55-0) → 2-amino-2-methyl-1-propanol hydrochloride (3207-12-3)

Guidance literature:

N-(1-cyano-1-methyl-ethyl)formamide; With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); water; hydrogen; In 1,4-dioxane; at 140 ℃; for 18h; under 45004.5 Torr; Autoclave;

With hydrogenchloride; water; In methanol; for 18h; Solvent;

Reference yield: 38.0%

isobutyl 2,2,2-trichloroacetimidate (107892-41-1) → 2-amino-2-methyl-1-propanol hydrochloride (3207-12-3)

Guidance literature:

isobutyl 2,2,2-trichloroacetimidate; With N-iodo-succinimide; In 1,2-dichloro-ethane; at 110 ℃; for 3h; Inert atmosphere; Sealed tube;

With hydrogenchloride; In tetrahydrofuran; water; 1,2-dichloro-ethane; at 20 ℃; for 5h; Inert atmosphere; Sealed tube;

DOI:10.1039/c7cc08897c

Reference yield:

N-(1-cyano-1-methyl-ethyl)formamide (58004-55-0) → N-(1-hydroxy-2-methylpropan-2-yl)formamide (682-85-9) + 2-amino-2-methyl-1-propanol hydrochloride (3207-12-3)

Guidance literature:

With ammonium dihydrogen phosphate; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); hydrogen; In 1,4-dioxane; water; at 150 ℃; for 48h; under 41254.1 Torr; Reagent/catalyst; Autoclave;

DOI:10.1002/chem.201900531

upstream raw materials:

isobutyl 2,2,2-trichloroacetimidate

N-(1-cyano-1-methyl-ethyl)formamide

N-(1-hydroxy-2-methylpropan-2-yl)formamide

Downstream raw materials:

β-Hydroxy-tert-butyl-trimethylammonium-iodid

2-amino-1-benzoyloxy-2-methyl-propane; hydrochloride

Refernces

• 1、 Calleja, Pilar,Ernst, Martin,Hashmi, A. Stephen K.,Schaub, Thomas. "Ruthenium-Catalyzed Deaminative Hydrogenation of Amino Nitriles: Direct Access to 1,2-Amino Alcohols". supporting information. p. 9498 - 9503. Retrieved 2019/04/30.
• 2、 -. "Carbacyclin analogs". . . Retrieved 2008/06/13.