1-{2-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-methylsulfanyl-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide

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Chemical Name:1-{2-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-methylsulfanyl-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide
CAS No.:1093160-76-9
Molecular Formula:C₃₅H₃₄F₂N₈O₂S
Molecular Weight:668.77
Hs Code.:

1-{2-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-methylsulfanyl-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide

Synonyms:1-{2-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-methylsulfanyl-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide

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Chemical Property of 1-{2-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-methylsulfanyl-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide

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Technology Process of 1-{2-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-methylsulfanyl-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide

There total 10 articles about 1-{2-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-methylsulfanyl-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093063-73-0
2-chloro-1-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethanone

: 1093063-68-3
C₁₉H₁₉FN₄OS

: 1093160-76-9
1-{2-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-methylsulfanyl-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 216393-64-5
(4-bromo-2-fluorophenyl)boronic acid

: 1093160-76-9
1-{2-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-methylsulfanyl-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 90 °C

2: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 100 °C

3: triethylamine / tetrahydrofuran / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1093063-71-8
2-(4-bromo-2-fluoro-phenyl)-pyrimidine

: 1093160-76-9
1-{2-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-methylsulfanyl-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 100 °C

2: triethylamine / tetrahydrofuran / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;