4-methyl-6,7-(methylenedioxy)-9-[2-(3,4,5-trimethoxyphenyl)ethyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one

Base Information

• Chemical Name: 4-methyl-6,7-(methylenedioxy)-9-[2-(3,4,5-trimethoxyphenyl)ethyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one
• CAS No.: 1260403-27-7
• Molecular Formula: C₂₄H₂₅NO₇
• Molecular Weight: 439.465
• Mol file: 1260403-27-7.mol

Synonyms:4-methyl-6,7-(methylenedioxy)-9-[2-(3,4,5-trimethoxyphenyl)ethyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one

Chemical Property of 4-methyl-6,7-(methylenedioxy)-9-[2-(3,4,5-trimethoxyphenyl)ethyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-6,7-(methylenedioxy)-9-[2-(3,4,5-trimethoxyphenyl)ethyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one

There total 5 articles about 4-methyl-6,7-(methylenedioxy)-9-[2-(3,4,5-trimethoxyphenyl)ethyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6,7-(methylenedioxy)-9-[(1E)-2-(3,4,5-trimethoxyphenyl)ethenyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one (1260403-31-3) → 4-methyl-6,7-(methylenedioxy)-9-[2-(3,4,5-trimethoxyphenyl)ethyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one (1260403-27-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 2h; under 7500.75 Torr;

DOI:10.1002/cmdc.201000305

Reference yield:

3-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enylidene]-furane-2,4(3H,5H)-dione (1260403-36-8) → 4-methyl-6,7-(methylenedioxy)-9-[2-(3,4,5-trimethoxyphenyl)ethyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one (1260403-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 1 h / Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 7500.75 Torr

With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane;

DOI:10.1002/cmdc.201000305

Reference yield:

(E)-3-(3,4,5-trimethoxyphenyl)acryloyl chloride (10263-19-1,89652-61-9) → 4-methyl-6,7-(methylenedioxy)-9-[2-(3,4,5-trimethoxyphenyl)ethyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one (1260403-27-7)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 0 - 20 °C

2: ethanol / 10 h / Reflux

3: dichloromethane / 1 h / Reflux

4: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 7500.75 Torr

With palladium 10% on activated carbon; hydrogen; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1002/cmdc.201000305

upstream raw materials:

3-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enylidene]-furane-2,4(3H,5H)-dione

6,7-(methylenedioxy)-9-[(1E)-2-(3,4,5-trimethoxyphenyl)ethenyl]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one

(E)-3,4,5-trimethoxy-cinnamic acid

3,4,5-trimethoxycinnamaldehyde