N-(3-acetylthio-2-methylpropanoyl)-N-phenylglycine tert-butyl ester

Base Information

• Chemical Name: N-(3-acetylthio-2-methylpropanoyl)-N-phenylglycine tert-butyl ester
• CAS No.: 78773-98-5
• Molecular Formula: C₁₈H₂₅NO₄S
• Molecular Weight: 351.467
• Mol file: 78773-98-5.mol

Synonyms:N-(3-acetylthio-2-methylpropanoyl)-N-phenylglycine tert-butyl ester

Chemical Property of N-(3-acetylthio-2-methylpropanoyl)-N-phenylglycine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-(3-acetylthio-2-methylpropanoyl)-N-phenylglycine tert-butyl ester

There total 3 articles about N-(3-acetylthio-2-methylpropanoyl)-N-phenylglycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → N-(3-acetylthio-2-methylpropanoyl)-N-phenylglycine tert-butyl ester (78773-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / ethanol / Ambient temperature

2: DCC / CH₂Cl₂ / 16 h / Ambient temperature

With triethylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1021/jm00379a013

Reference yield:

aniline (62-53-3) → N-(3-acetylthio-2-methylpropanoyl)-N-phenylglycine tert-butyl ester (78773-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / ethanol / Ambient temperature

2: DCC / CH₂Cl₂ / 16 h / Ambient temperature

With triethylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1021/jm00379a013

Reference yield:

3-(acetylthio)-2-methylpropanoic acid (33325-40-5) + tert-butyl 2-(phenylamino)acetate (65171-67-7) → N-(3-acetylthio-2-methylpropanoyl)-N-phenylglycine tert-butyl ester (78773-98-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; for 16h; Ambient temperature;

DOI:10.1021/jm00379a013

upstream raw materials:

3-(acetylthio)-2-methylpropanoic acid

tert-butyl 2-(phenylamino)acetate

bromoacetic acid tert-butyl ester

aniline

Downstream raw materials:

N-(3-acetylthio-2-methylpropanoyl)-N-phenylglycine

N-[2'-methyl-3'-mercaptopropionyl]-D-phenylglycine