C₄₈H₆₇N₅O₆

Base Information

• Chemical Name: C₄₈H₆₇N₅O₆
• CAS No.: 1009093-32-6
• Molecular Formula: C₄₈H₆₇N₅O₆
• Molecular Weight: 810.09
• Mol file: 1009093-32-6.mol

Synonyms:C₄₈H₆₇N₅O₆

Chemical Property of C₄₈H₆₇N₅O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₆₇N₅O₆

There total 11 articles about C₄₈H₆₇N₅O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.1%

(+)-(S)-2-amino-1-phenyl-3-(pyrrolidin-1-yl)propane (200267-75-0) + C35H49N3O7 (1009094-68-1) → C48H67N5O6 (1009093-32-6)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

C9H10BrNO2 → C48H67N5O6 (1009093-32-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: hydrogenchloride; methyl orange; sodium cyanoborohydride / tetrahydrofuran; methanol; water / 16 h / pH 2

1.2: pH 7 / Alkaline aqueous solution

2.1: benzene / Heating / reflux

3.1: titanium(IV) isopropylate / toluene / 0.17 h / 120 °C / Microwave irradiation

3.2: 1 h

4.1: pyridine hydrogenfluoride / tetrahydrofuran / 3 h / 20 °C

5.1: trimethylaluminum / hexanes; dichloromethane / 0.25 h / 20 °C

5.2: 16 h / 20 °C

5.3: 2 h / 20 °C

6.1: potassium acetate; caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4.5 h / 60 °C

7.1: sodium cyanoborohydride; acetic acid / methanol; water / 20 °C

8.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 1 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; methyl orange; trimethylaluminum; potassium acetate; sodium cyanoborohydride; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; pyridine hydrogenfluoride; acetic acid; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; hexanes; dichloromethane; water; dimethyl sulfoxide; toluene; benzene;

Reference yield:

C9H12BrNO2 (1009091-83-1) → C48H67N5O6 (1009093-32-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: benzene / Heating / reflux

2.1: titanium(IV) isopropylate / toluene / 0.17 h / 120 °C / Microwave irradiation

2.2: 1 h

3.1: pyridine hydrogenfluoride / tetrahydrofuran / 3 h / 20 °C

4.1: trimethylaluminum / hexanes; dichloromethane / 0.25 h / 20 °C

4.2: 16 h / 20 °C

4.3: 2 h / 20 °C

5.1: potassium acetate; caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4.5 h / 60 °C

6.1: sodium cyanoborohydride; acetic acid / methanol; water / 20 °C

7.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 1 h / 20 °C

With titanium(IV) isopropylate; trimethylaluminum; potassium acetate; sodium cyanoborohydride; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; pyridine hydrogenfluoride; acetic acid; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; hexanes; dichloromethane; water; dimethyl sulfoxide; toluene; benzene;

upstream raw materials:

(+)-(S)-2-amino-1-phenyl-3-(pyrrolidin-1-yl)propane

C₃₅H₄₉N₃O₇

C₉H₁₂BrNO₂

C₁₂H₁₄BrNO₄