(2R,4S)-2-benzyl-3-((2-phenylethyl)sulfonimidoyl)propionic acid hydrochloride

Base Information

• Chemical Name: (2R,4S)-2-benzyl-3-((2-phenylethyl)sulfonimidoyl)propionic acid hydrochloride
• CAS No.: 129967-52-8
• Molecular Formula: C₁₈H₂₁NO₃S*ClH
• Molecular Weight: 367.897
• Mol file: 129967-52-8.mol

Synonyms:(2R,4S)-2-benzyl-3-((2-phenylethyl)sulfonimidoyl)propionic acid hydrochloride

Chemical Property of (2R,4S)-2-benzyl-3-((2-phenylethyl)sulfonimidoyl)propionic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4S)-2-benzyl-3-((2-phenylethyl)sulfonimidoyl)propionic acid hydrochloride

There total 7 articles about (2R,4S)-2-benzyl-3-((2-phenylethyl)sulfonimidoyl)propionic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

trans-L-(+)-4,5-dihydro-1-(2-phenylethyl)-4-(phenylmethyl)-3H-1λ4-isothiazol-3-one 1-oxide (129967-51-7,130060-22-9,130060-24-1,130060-25-2) → (2R,4S)-2-benzyl-3-((2-phenylethyl)sulfonimidoyl)propionic acid hydrochloride (129967-52-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1021/jo00309a025

Reference yield:

chloromethyl 2-phenylethyl sulfide (90416-55-0) → (2R,4S)-2-benzyl-3-((2-phenylethyl)sulfonimidoyl)propionic acid hydrochloride (129967-52-8)

Guidance literature:

Multi-step reaction with 6 steps

1: ethanol / 0.5 h / 80 °C

2: 54 percent / aq. potassium hydroxide

3: Heating

4: 86 percent / sodium metaperiodate / methanol; H₂O

5: 16 percent / CH₂Cl₂ / 24 h / 25 °C

6: 59 percent / conc. HCl / tetrahydrofuran / 24 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium periodate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

DOI:10.1021/jo00309a025

Reference yield:

sodium diethyl benzylmalonate → (2R,4S)-2-benzyl-3-((2-phenylethyl)sulfonimidoyl)propionic acid hydrochloride (129967-52-8)

Guidance literature:

Multi-step reaction with 6 steps

1: ethanol / 0.5 h / 80 °C

2: 54 percent / aq. potassium hydroxide

3: Heating

4: 86 percent / sodium metaperiodate / methanol; H₂O

5: 16 percent / CH₂Cl₂ / 24 h / 25 °C

6: 59 percent / conc. HCl / tetrahydrofuran / 24 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium periodate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

DOI:10.1021/jo00309a025

upstream raw materials:

trans-L-(+)-4,5-dihydro-1-(2-phenylethyl)-4-(phenylmethyl)-3H-1λ⁴-isothiazol-3-one 1-oxide

chloromethyl 2-phenylethyl sulfide

2-(((2-phenylethyl)thio)methyl)-2-benzylmalonic acid

L-2-benzyl-3-((2-phenylethyl)thio)propionic acid