3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylacrylamide

Base Information

Chemical Name:3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylacrylamide
CAS No.:1307895-82-4
Molecular Formula:C₂₃H₂₆N₆O₂
Molecular Weight:418.498
Hs Code.:

Synonyms:3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylacrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylacrylamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylacrylamide

There total 9 articles about 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₄₀N₆O₂Si

: 1307895-82-4
3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylacrylamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1.5h;

Reference yield:

: 52573-74-7
2-cyano-N-isopropylacetamide

: 1307895-82-4
3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / tetrahydrofuran / 96 h / 20 °C

2: hydrogenchloride / tetrahydrofuran; water / 1.5 h / 20 °C

With piperidine; hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 1307896-58-7
N'-(3-cyano-4-p-tolyl-1H-pyrrol-2-yl)formimidamide

: 1307895-82-4
3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylacrylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / methanol / 3 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2.2: 4 h

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 24 h

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 3 h / Inert atmosphere

5.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

6.1: piperidine / tetrahydrofuran / 96 h / 20 °C

7.1: hydrogenchloride / tetrahydrofuran; water / 1.5 h / 20 °C

With piperidine; hydrogenchloride; sodium periodate; N-Bromosuccinimide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; sodium hydride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;