9-{[({N-[2-(benzyloxy)benzoyl]sulfamoyl}-oxy)ethoxy]methyl}adenine

Base Information

• Chemical Name: 9-{[({N-[2-(benzyloxy)benzoyl]sulfamoyl}-oxy)ethoxy]methyl}adenine
• CAS No.: 939794-99-7
• Molecular Formula: C₂₂H₂₂N₆O₆S
• Molecular Weight: 498.519
• Mol file: 939794-99-7.mol

Synonyms:9-{[({N-[2-(benzyloxy)benzoyl]sulfamoyl}-oxy)ethoxy]methyl}adenine

Chemical Property of 9-{[({N-[2-(benzyloxy)benzoyl]sulfamoyl}-oxy)ethoxy]methyl}adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-{[({N-[2-(benzyloxy)benzoyl]sulfamoyl}-oxy)ethoxy]methyl}adenine

There total 3 articles about 9-{[({N-[2-(benzyloxy)benzoyl]sulfamoyl}-oxy)ethoxy]methyl}adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

→ 9-{[({N-[2-(benzyloxy)benzoyl]sulfamoyl}-oxy)ethoxy]methyl}adenine (939794-99-7)

Guidance literature:

Reference yield:

Sulfamic acid 2-(6-amino-purin-9-ylmethoxy)-ethyl ester (75128-52-8) + N-[(2-benzyloxyphenyl)carboxy]succinimide (287971-19-1) → 9-{[({N-[2-(benzyloxy)benzoyl]sulfamoyl}-oxy)ethoxy]methyl}adenine (939794-99-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jm061068d

Reference yield:

9-[(2-hydroxyethoxy)methyl]adenine (31383-66-1) → 9-{[({N-[2-(benzyloxy)benzoyl]sulfamoyl}-oxy)ethoxy]methyl}adenine (939794-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / 1,2-dimethoxy-ethane

1.2: 45 percent / NH₂SO₂Cl / 1,2-dimethoxy-ethane

2.1: DBU / dimethylformamide / 16 h / 20 °C

With sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;

DOI:10.1021/jm061068d

upstream raw materials:

Sulfamic acid 2-(6-amino-purin-9-ylmethoxy)-ethyl ester

N-[(2-benzyloxyphenyl)carboxy]succinimide

9-[(2-hydroxyethoxy)methyl]adenine