ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

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Chemical Name:ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
CAS No.:427877-66-5
Molecular Formula:C₁₉H₂₁N₅O₄
Molecular Weight:383.407
Hs Code.:

Synonyms:ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

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Chemical Property of ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

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Technology Process of ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

There total 7 articles about ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 427878-41-9
4-chloro-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester

: N-methoxy-3-amino-4-methylbenzamide hydrochloride

: 427877-66-5
ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 55 ℃; for 10h;
DOI:10.1021/jm7009414

Reference yield:

: ethyl 2-(((2-ethoxy-2-oxoethyl)amino)methylene)-3-oxobutanoate

: 427877-66-5
ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium 2-methylbutan-2-olate; ethyl trifluoroacetate, / ethanol; toluene / 9 h / 60 - 63 °C / Large scale

2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 20 - 37 °C / Large scale

3: formamide; phosphoric acid / 120 °C

4: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 2 h / 110 °C

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 58 °C / Large scale

With ethyl trifluoroacetate,; phosphoric acid; potassium tert-butylate; potassium 2-methylbutan-2-olate; formamide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op300181r

Reference yield:

: 141-97-9
ethyl acetoacetate

: 427877-66-5
ethyl 4-((5-(methoxycarbamoyl)-2-methylphenyl)-amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: p-toluenesulfonic acid monohydrate / 1 h / 55 - 60 °C

2: ethanol / 0.5 h / 45 - 53 °C / Large scale

3: potassium 2-methylbutan-2-olate; ethyl trifluoroacetate, / ethanol; toluene / 9 h / 60 - 63 °C / Large scale

4: potassium tert-butylate / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 20 - 37 °C / Large scale

5: formamide; phosphoric acid / 120 °C

6: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 2 h / 110 °C

7: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 58 °C / Large scale

With ethyl trifluoroacetate,; phosphoric acid; potassium tert-butylate; p-toluenesulfonic acid monohydrate; potassium 2-methylbutan-2-olate; formamide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op300181r