5-Chloro-2-fluoro-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

Base Information

Chemical Name:5-Chloro-2-fluoro-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide
CAS No.:1354786-08-5
Molecular Formula:C₂₇H₁₆ClF₄N₅O₃S
Molecular Weight:601.968
Hs Code.:

Synonyms:5-Chloro-2-fluoro-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

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Chemical Property of 5-Chloro-2-fluoro-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

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Technology Process of 5-Chloro-2-fluoro-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

There total 4 articles about 5-Chloro-2-fluoro-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1354786-89-2
5-Chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

: 1354786-08-5
5-Chloro-2-fluoro-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;

Reference yield:

: 1354786-58-5
4-chloro-2-pyridazin-4-ylphenol

: 1354786-08-5
5-Chloro-2-fluoro-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

2: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; water; dimethyl sulfoxide; 1: Suzuki Coupling;

Reference yield:

: 1354786-57-4
4-(5-chloro-2-methoxyphenyl)pyridazine

: 1354786-08-5
5-Chloro-2-fluoro-4-{[3-pyridazin-4-yl-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 18 h / 20 °C

1.2: pH 8 / Cooling with ice

2.1: potassium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

3.1: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; boron tribromide; potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; 2.1: Suzuki Coupling;