4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide

Base Information

• Chemical Name: 4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide
• CAS No.: 936028-23-8
• Molecular Formula: C₁₇H₁₅BrN₂O₃S
• Molecular Weight: 407.288
• Mol file: 936028-23-8.mol

Synonyms:4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide

Chemical Property of 4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide

There total 1 articles about 4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(bromomethyl)benzene-1-sulfonyl chloride (66176-39-4) + 8-amino-6-methoxy-quinoline hydrobromide (106492-78-8,312693-53-1) → 4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide (936028-23-8)

Guidance literature:

With pyridine; In dichloromethane; acetone; at 0 ℃; for 0.333333h;

DOI:10.1002/chem.200600624

Reference yield:

4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide (936028-23-8) → 4-((3-butyl-ureido)methyl)-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / sodium azide / dimethylformamide / 20 °C

2: 46 percent / hydrogen / Pd/C / CH₂Cl₂; methanol / 2 h / 20 °C

3: 97 percent / tetrahydrofuran / -10 °C

With sodium azide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.200600624

Reference yield:

4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide (936028-23-8) → 4-aminomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide (936028-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / sodium azide / dimethylformamide / 20 °C

2: 46 percent / hydrogen / Pd/C / CH₂Cl₂; methanol / 2 h / 20 °C

With sodium azide; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.200600624

upstream raw materials:

4-(bromomethyl)benzene-1-sulfonyl chloride

8-amino-6-methoxy-quinoline hydrobromide

Downstream raw materials:

4-aminomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide