ethyl (R)-3-(4-(tert-butyldimethylsilyloxy)phenyl)-3-((R)-1,1-dimethylethylsulfinamido)-2,2-difluoropropanoate

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Chemical Name:ethyl (R)-3-(4-(tert-butyldimethylsilyloxy)phenyl)-3-((R)-1,1-dimethylethylsulfinamido)-2,2-difluoropropanoate
CAS No.:1003317-74-5
Molecular Formula:C₂₁H₃₅F₂NO₄SSi
Molecular Weight:463.662
Hs Code.:

Synonyms:ethyl (R)-3-(4-(tert-butyldimethylsilyloxy)phenyl)-3-((R)-1,1-dimethylethylsulfinamido)-2,2-difluoropropanoate

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Chemical Property of ethyl (R)-3-(4-(tert-butyldimethylsilyloxy)phenyl)-3-((R)-1,1-dimethylethylsulfinamido)-2,2-difluoropropanoate

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Technology Process of ethyl (R)-3-(4-(tert-butyldimethylsilyloxy)phenyl)-3-((R)-1,1-dimethylethylsulfinamido)-2,2-difluoropropanoate

There total 1 articles about ethyl (R)-3-(4-(tert-butyldimethylsilyloxy)phenyl)-3-((R)-1,1-dimethylethylsulfinamido)-2,2-difluoropropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1003317-82-5
(R)-N-(4-(tert-butyldimethylsilyloxy)benzylidene)-2-methylpropane-2-sulfinamide

: 667-27-6
Ethyl bromodifluoroacetate

: 1003317-74-5
ethyl (R)-3-(4-(tert-butyldimethylsilyloxy)phenyl)-3-((R)-1,1-dimethylethylsulfinamido)-2,2-difluoropropanoate

Guidance literature:: Ethyl bromodifluoroacetate; With zinc; In tetrahydrofuran; at 30 ℃; for 0.0833333h;

(R)-N-(4-(tert-butyldimethylsilyloxy)benzylidene)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; at 20 ℃; for 48h; Further stages.;
DOI:10.1021/ja0762689

Reference yield: 55.0%

: 1003317-74-5
ethyl (R)-3-(4-(tert-butyldimethylsilyloxy)phenyl)-3-((R)-1,1-dimethylethylsulfinamido)-2,2-difluoropropanoate

: 1003317-78-9
(R)-3-amino-2,2-difluoro-3-(4-hydroxyphenyl)propanoic acid

Guidance literature:: ethyl (R)-3-(4-(tert-butyldimethylsilyloxy)phenyl)-3-((R)-1,1-dimethylethylsulfinamido)-2,2-difluoropropanoate; With hydrogenchloride; for 2.5h; Heating;

With methyloxirane; In isopropyl alcohol; at 20 ℃; for 12h; Further stages.;
DOI:10.1016/j.bmcl.2007.11.046