N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylmelphalanylleucine

Base Information

Chemical Name:N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylmelphalanylleucine
CAS No.:109334-90-9
Molecular Formula:C₅₀H₆₄Cl₂N₆O₇
Molecular Weight:932
Hs Code.:

Synonyms:N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylmelphalanylleucine

Suppliers and Price of N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylmelphalanylleucine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylmelphalanylleucine

Chemical Property:

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Technology Process of N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylmelphalanylleucine

There total 16 articles about N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylmelphalanylleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.6%

: 109335-02-6
N,N-dibenzyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylmelphalanylleucine tert-butyl ester

: 109334-90-9
N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylmelphalanylleucine

Guidance literature:: With methoxybenzene; trifluoroacetic acid; In dichloromethane; at 0 - 25 ℃; for 0.0541667h;
DOI:10.1021/jm00392a025

Reference yield:

: 6671-25-6
2-(2-benzyloxycarbonylamino-2-methyl-propionylamino)-2-methylpropionic acid methyl ester

: 109334-90-9
N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylmelphalanylleucine

Guidance literature:: Multi-step reaction with 8 steps

1: 87.2 percent / H₂, conc. HCl / 10percent Pd/C / methanol / 0.75 h / 760 Torr

2: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 1.) -15 deg C, 45 min, 2.) 25 deg C, 2.5 h

3: 73.8 percent / ammonium formate / 10percent Pd/C / methanol / 0.25 h / 25 °C

4: 84.3 percent / N,N-diisopropylethylamine / acetonitrile / 18 h / 25 °C

5: 94.9 percent / 4N NaOH / methanol; tetrahydrofuran / 18 h / 25 °C

6: Et₃N / toluene / 4.5 h / -5 - 25 °C

7: toluene / 18 h / 25 °C

8: 94.6 percent / TFA, anisole / CH₂Cl₂ / 0.05 h / 0 - 25 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; ammonium formate; methoxybenzene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm00392a025

Reference yield:

: 148-82-3,8057-25-8
L-PAM

: 109334-90-9
N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylmelphalanylleucine

Guidance literature:: Multi-step reaction with 6 steps

1: 70.4 percent / Na₂CO₃, 1.0 N NaOH / 4.5 h / 0 - 5 °C

2: N-methylmorpholine / tetrahydrofuran / 0.03 h / -18 - -12 °C

3: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 1.) -15 deg C, 30 min, 2.) 25 deg C, 1.5 h

4: 83.5 percent / ammonium formate / 10percent Pd/C / methanol

5: toluene / 18 h / 25 °C

6: 94.6 percent / TFA, anisole / CH₂Cl₂ / 0.05 h / 0 - 25 °C

With 4-methyl-morpholine; sodium hydroxide; ammonium formate; sodium carbonate; methoxybenzene; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00392a025