(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-propargylpiperazine

Base Information

Chemical Name:(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-propargylpiperazine
CAS No.:218592-73-5
Molecular Formula:C₂₅H₂₄F₆N₂O
Molecular Weight:482.469
Hs Code.:

Synonyms:(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-propargylpiperazine

Suppliers and Price of (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-propargylpiperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-propargylpiperazine

Chemical Property:

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Technology Process of (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-propargylpiperazine

There total 1 articles about (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-propargylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 169458-94-0
(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)piperazine

: 106-96-7
propargyl bromide

: 218592-73-5
(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-propargylpiperazine

Guidance literature:: With potassium carbonate; In N-methyl-acetamide; hexane; ethyl acetate;

Reference yield:

: 218595-25-6
(3S)-3-methoxymethylmorpholine

: 218592-73-5
(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-propargylpiperazine

: 218785-45-6
(2R)-1-[3,5-bis-(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-[4-((3S)-3-methoxymethylmorpholino)-2-butynyl]piperazine

Guidance literature:: With sodium bicarbonate; N-ethyl-N,N-diisopropylamine; paraformaldehyde; copper(I) iodide; In 1,4-dioxane; methanol; chloroform; ethyl acetate;

Reference yield:

: 218592-73-5
(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-propargylpiperazine

: (2R)-1-(3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dimethylbenzyl)-4-[4-((3S)-3-methoxymethylmorpholino)butyl]piperazine dihydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium bicarbonate; N-ethyl-N,N-diisopropylamine; paraformaldehyde / copper(I) iodide / 1,4-dioxane; methanol; chloroform; ethyl acetate

With sodium bicarbonate; N-ethyl-N,N-diisopropylamine; paraformaldehyde; copper(I) iodide; In 1,4-dioxane; methanol; chloroform; ethyl acetate;