2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3,4-dimethoxyphenyl)acetamide

Base Information

• Chemical Name: 2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3,4-dimethoxyphenyl)acetamide
• CAS No.: 1385049-64-8
• Molecular Formula: C₂₂H₂₂N₂O₈
• Molecular Weight: 442.425
• Mol file: 1385049-64-8.mol

Synonyms:2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3,4-dimethoxyphenyl)acetamide

Chemical Property of 2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3,4-dimethoxyphenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3,4-dimethoxyphenyl)acetamide

There total 4 articles about 2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3,4-dimethoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.8%

C10H12INO3 (1393083-48-1) + N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen-3-yl)acetamide (1385049-56-8) → 2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3,4-dimethoxyphenyl)acetamide (1385049-64-8)

Guidance literature:

With potassium carbonate; In acetone; for 2h; Reflux;

DOI:10.1016/j.bmcl.2012.06.014

Reference yield:

3,4-dimethoxyaniline (6315-89-5) → 2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3,4-dimethoxyphenyl)acetamide (1385049-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 4 h / 0 - 20 °C

2: potassium iodide / acetone / 2 h / Reflux

3: potassium carbonate / acetone / 2 h / Reflux

With potassium carbonate; acetic acid; potassium iodide; In acetone; 2: Finkelstein reaction;

DOI:10.1016/j.bmcl.2012.06.014

Reference yield:

2-chloro-N1-(3,4-dimethoxyphenyl)-acetamide (62593-78-6) → 2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3,4-dimethoxyphenyl)acetamide (1385049-64-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium iodide / acetone / 2 h / Reflux

2: potassium carbonate / acetone / 2 h / Reflux

With potassium carbonate; potassium iodide; In acetone; 1: Finkelstein reaction;

DOI:10.1016/j.bmcl.2012.06.014

upstream raw materials:

C₁₀H₁₂INO₃

N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen-3-yl)acetamide

3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yl acetate

2-chloro-N¹-(3,4-dimethoxyphenyl)-acetamide