2-fluoro-5-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]benzoic acid

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Chemical Name:2-fluoro-5-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]benzoic acid
CAS No.:1443283-33-7
Molecular Formula:C₂₀H₁₁F₄N₃O₂
Molecular Weight:401.32
Hs Code.:

Synonyms:2-fluoro-5-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]benzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-fluoro-5-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]benzoic acid

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Technology Process of 2-fluoro-5-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]benzoic acid

There total 2 articles about 2-fluoro-5-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874219-36-0
[3-(ethoxycarbonyl)-4-fluorophenyl]boronic acid

: 1443283-93-9
6-bromo-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

: 1443283-33-7
2-fluoro-5-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]benzoic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; water; at 150 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 827-41-8
3-phenylpyrazol-5-amine

: 1443283-33-7
2-fluoro-5-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; water / 18 h / 90 °C

2: phosphorus(V) oxybromide / toluene / 18 h / 90 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; tetrahydrofuran / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; caesium carbonate; acetic acid; phosphorus(V) oxybromide; In tetrahydrofuran; water; toluene; 3: |Suzuki Coupling;