3-(2,5-dimethoxy-4-methyl-phenyl)-2-methyl-but-2-enoic acid ethyl ester

Base Information

• Chemical Name: 3-(2,5-dimethoxy-4-methyl-phenyl)-2-methyl-but-2-enoic acid ethyl ester
• CAS No.: 936734-66-6
• Molecular Formula: C₁₆H₂₂O₄
• Molecular Weight: 278.348
• Mol file: 936734-66-6.mol

Synonyms:3-(2,5-dimethoxy-4-methyl-phenyl)-2-methyl-but-2-enoic acid ethyl ester

Chemical Property of 3-(2,5-dimethoxy-4-methyl-phenyl)-2-methyl-but-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,5-dimethoxy-4-methyl-phenyl)-2-methyl-but-2-enoic acid ethyl ester

There total 1 articles about 3-(2,5-dimethoxy-4-methyl-phenyl)-2-methyl-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 2-diethoxyphosphorylpropionate (3699-66-9) + 1-(2,5-Dimethoxy-4-methyl-phenyl)-ethanone (13720-58-6) → 3-(2,5-dimethoxy-4-methyl-phenyl)-2-methyl-but-2-enoic acid ethyl ester (936734-66-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 8h; Heating;

DOI:10.1055/s-2007-967971

Reference yield: 93.0%

3-(2,5-dimethoxy-4-methyl-phenyl)-2-methyl-but-2-enoic acid ethyl ester (936734-66-6) → 3-(2,5-dimethoxy-4-methyl-phenyl)-2-methyl-but-2-en-1-ol (936734-67-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at -50 ℃; for 2h;

DOI:10.1055/s-2007-967971

Reference yield:

3-(2,5-dimethoxy-4-methyl-phenyl)-2-methyl-but-2-enoic acid ethyl ester (936734-66-6) → 4-(2,5-dimethoxy-4-methylphenyl)-4,5-dimethylbicyclo[3.1.0]hexan-2-one (936734-71-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 93 percent / lithium aluminum hydride / diethyl ether / 2 h / -50 °C

2: 90 percent / propionic acid / 48 h / 180 °C

3: 92 percent / sodium hydroxide / aq. methanol / 4 h / Heating

4: oxalyl chloride / benzene / 3 h / 20 °C

5: diethyl ether / 1 h / 0 °C

6: 48 percent / copper / copper sulfate / cyclohexane / 6 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; copper; propionic acid; copper(I) sulfate; copper(II) sulfate; In methanol; diethyl ether; cyclohexane; benzene; 2: Claisen rearrangement;

DOI:10.1055/s-2007-967971

upstream raw materials:

ethyl 2-diethoxyphosphorylpropionate

1-(2,5-Dimethoxy-4-methyl-phenyl)-ethanone

Downstream raw materials:

3-(2,5-dimethoxy-4-methyl-phenyl)-2-methyl-but-2-en-1-ol

4-(2,5-dimethoxy-4-methylphenyl)-4,5-dimethylbicyclo[3.1.0]hexan-2-one

3-(2,5-dimethoxy-4-methyl-phenyl)-3,4-dimethyl-pent-4-enoic acid

1-diazo-4-(2,5-dimethoxy-4-methyl-phenyl)-4,5-dimethyl-hex-5-en-2-one