(S)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-N-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide

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Chemical Name:(S)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-N-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide
CAS No.:1236007-01-4
Molecular Formula:C₂₀H₂₇N₃O₅
Molecular Weight:389.451
Hs Code.:

Synonyms:(S)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-N-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide

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Chemical Property of (S)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-N-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide

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Technology Process of (S)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-N-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide

There total 12 articles about (S)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-N-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1236006-68-0
C₂₈H₃₅N₃O₆

: 1236007-01-4
(S)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-N-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2014.07.106

Reference yield:

: C₂₄H₃₂N₂O₈

: 1236007-01-4
(S)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-N-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: ethyl acetate / 12 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With trifluoroacetic acid; In dichloromethane; ethyl acetate;
DOI:10.1016/j.ejmech.2014.07.106

Reference yield:

: C₁₂H₂₀O₃

: 1236007-01-4
(S)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)-N-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: 24 h / 45 °C / Inert atmosphere

2.2: 1.5 h / Inert atmosphere

2.3: 0.5 h / Inert atmosphere

3.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 1 h / 0 °C

4.1: 20 - 60 °C

5.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

6.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 1 h / 20 °C

7.1: tetrahydrofuran / 1 h / 0 - 20 °C

8.1: ethyl acetate / 12 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With 4-methyl-morpholine; n-butyllithium; lithium hydroxide monohydrate; dihydrogen peroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.ejmech.2014.07.106