5-(4-(2-hydroxypropan-2-yl)phenylamino)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile

Base Information

Chemical Name:5-(4-(2-hydroxypropan-2-yl)phenylamino)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile
CAS No.:1413065-18-5
Molecular Formula:C₁₉H₂₈N₄O₂Si
Molecular Weight:372.542
Hs Code.:

Synonyms:5-(4-(2-hydroxypropan-2-yl)phenylamino)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile

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Chemical Property of 5-(4-(2-hydroxypropan-2-yl)phenylamino)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile

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Technology Process of 5-(4-(2-hydroxypropan-2-yl)phenylamino)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile

There total 2 articles about 5-(4-(2-hydroxypropan-2-yl)phenylamino)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 2077-19-2
2-(4-bromophenyl)propan-2-ol

: 1207176-38-2
5-amino-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile

: 1413065-18-5
5-(4-(2-hydroxypropan-2-yl)phenylamino)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile

Guidance literature:: With caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In toluene; at 20 - 120 ℃; Inert atmosphere;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1413065-18-5
5-(4-(2-hydroxypropan-2-yl)phenylamino)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

1.2: 1 h / 20 °C

2.1: caesium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 20 - 120 °C / Inert atmosphere

With sodium hydride; caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield: 47.0%

: 1413065-18-5
5-(4-(2-hydroxypropan-2-yl)phenylamino)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile

: 1413065-22-1
3-(4-(2-hydroxypropan-2-yl)phenylamino)-1H-pyrazol-4-carbonitrile

Guidance literature:: 5-(4-(2-hydroxypropan-2-yl)phenylamino)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile; With tetrabutyl ammonium fluoride; at 110 ℃; for 28h; Sealed flask;

With water; In diethyl ether; at 20 ℃;