(S)-2-{(S)-2-[(1R,2R)-1-Methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Chemical Name:(S)-2-{(S)-2-[(1R,2R)-1-Methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
CAS No.:205498-82-4
Molecular Formula:C₄₀H₄₄N₄O₅S
Molecular Weight:692.879
Hs Code.:

(S)-2-{(S)-2-[(1R,2R)-1-Methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Synonyms:(S)-2-{(S)-2-[(1R,2R)-1-Methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of (S)-2-{(S)-2-[(1R,2R)-1-Methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of (S)-2-{(S)-2-[(1R,2R)-1-Methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

There total 1 articles about (S)-2-{(S)-2-[(1R,2R)-1-Methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 71989-31-6
Fmoc-Pro-OH

: (2R,3R)-3-methoxy-2-methyl-N-[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]-3-[(2S)-pyrrolidin-2-yl]propanamide hydrochloric acid

: 205498-82-4
(S)-2-{(S)-2-[(1R,2R)-1-Methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jm970800t

Reference yield:

: 205498-82-4
(S)-2-{(S)-2-[(1R,2R)-1-Methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

: 205498-80-2
(2R,3R)-3-Methoxy-2-methyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-3-[(S)-1-((S)-pyrrolidine-2-carbonyl)-pyrrolidin-2-yl]-propionamide

Guidance literature:: With diethylamine; In N,N-dimethyl-formamide; for 0.5h; Ambient temperature;
DOI:10.1021/jm970800t

Reference yield:

: 205498-82-4
(S)-2-{(S)-2-[(1R,2R)-1-Methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

: (2R,3R)-3-Methoxy-2-methyl-3-{(S)-1-[(S)-1-((S)-3-methyl-2-methylamino-butyryl)-pyrrolidine-2-carbonyl]-pyrrolidin-2-yl}-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 0.124 g / Et₂NH / dimethylformamide / 0.5 h / Ambient temperature

2: 92 percent / diisopropylethylamine, tris(dimethylamino)bromophosphonium hexahfluorophosphate / CH₂Cl₂ / 1 h / Ambient temperature

3: Et₂NH / dimethylformamide / 0.5 h / Ambient temperature

With bromo-tris-dimethylamino-phosphonium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970800t