6-({[(1R)-1-(4-fluorophenyl)ethyl](quinolin-3-ylcarbonyl)amino}methyl)pyridine-2-carboxylic acid

Base Information

Chemical Name:6-({[(1R)-1-(4-fluorophenyl)ethyl](quinolin-3-ylcarbonyl)amino}methyl)pyridine-2-carboxylic acid
CAS No.:1398583-33-9
Molecular Formula:C₂₅H₂₀FN₃O₃
Molecular Weight:429.451
Hs Code.:

Synonyms:6-({[(1R)-1-(4-fluorophenyl)ethyl](quinolin-3-ylcarbonyl)amino}methyl)pyridine-2-carboxylic acid

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Chemical Property of 6-({[(1R)-1-(4-fluorophenyl)ethyl](quinolin-3-ylcarbonyl)amino}methyl)pyridine-2-carboxylic acid

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Technology Process of 6-({[(1R)-1-(4-fluorophenyl)ethyl](quinolin-3-ylcarbonyl)amino}methyl)pyridine-2-carboxylic acid

There total 5 articles about 6-({[(1R)-1-(4-fluorophenyl)ethyl](quinolin-3-ylcarbonyl)amino}methyl)pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: C₂₆H₂₂FN₃O₃

: 1398583-33-9
6-({[(1R)-1-(4-fluorophenyl)ethyl](quinolin-3-ylcarbonyl)amino}methyl)pyridine-2-carboxylic acid

Guidance literature:: With lithium hydroxide; In methanol; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ml500479v

Reference yield:

: 374898-01-8
(R)-1-(4-fluorophenyl)ethylamine

: 1398583-33-9
6-({[(1R)-1-(4-fluorophenyl)ethyl](quinolin-3-ylcarbonyl)amino}methyl)pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 20 °C / Inert atmosphere

3: lithium hydroxide / methanol / 5 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; triethylamine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1021/ml500479v

Reference yield:

: 1398583-88-4
methyl 6-({[(1R)-1-(4-fluorophenyl)ethyl]amino}methyl)pyridine-2-carboxylate

: 1398583-33-9
6-({[(1R)-1-(4-fluorophenyl)ethyl](quinolin-3-ylcarbonyl)amino}methyl)pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: lithium hydroxide / methanol / 5 h / 20 °C / Inert atmosphere

With triethylamine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1021/ml500479v