N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-3-methoxypropanamide

Base Information

Chemical Name:N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-3-methoxypropanamide
CAS No.:1036403-48-1
Molecular Formula:C₁₈H₂₁FN₄O₃
Molecular Weight:360.388
Hs Code.:

Synonyms:N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-3-methoxypropanamide

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Chemical Property of N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-3-methoxypropanamide

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Technology Process of N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-3-methoxypropanamide

There total 6 articles about N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-3-methoxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 2544-06-1
3-Methoxypropionic acid

: 8-(3-amino-4-fluorobenzyl)-2,3,4,6-tetrahydropyrido[2,3-d]pyridazin-5(1H)-one trifluoroacetate

: 1036403-48-1
N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-3-methoxypropanamide

Guidance literature:: 3-Methoxypropionic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

8-(3-amino-4-fluorobenzyl)-2,3,4,6-tetrahydropyrido[2,3-d]pyridazin-5(1H)-one trifluoroacetate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2012.06.021

Reference yield:

: 1036403-18-5
8-(3-amino-4-fluorobenzyl)pyrido[2,3-d]pyridazin-5(6H)-one

: 1036403-48-1
N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-3-methoxypropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; platinum on carbon; hydrogen / water; N,N-dimethyl-formamide / 16 h / 20 °C / 2585.81 Torr / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: 20 °C

With hydrogenchloride; platinum on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.06.021

Reference yield:

: 1036403-14-1
2-fluoro-5-[(5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-8-yl)methyl]benzamide

: 1036403-48-1
N-{2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]phenyl}-3-methoxypropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; potassium hydroxide / 1.17 h / -10 - 65 °C / Inert atmosphere

2.1: hydrogenchloride; platinum on carbon; hydrogen / water; N,N-dimethyl-formamide / 16 h / 20 °C / 2585.81 Torr / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

3.2: 20 °C

With hydrogenchloride; platinum on carbon; hydrogen; bromine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.06.021