Technology Process of 4-[S-phenyl-N-(pyridin-3-yl)sulfonimidoyl]morpholine
There total 15 articles about 4-[S-phenyl-N-(pyridin-3-yl)sulfonimidoyl]morpholine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate;
In
tetrahydrofuran;
at 100 ℃;
for 2.5h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1016/j.tet.2012.06.072
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / dichloromethane / 3.33 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / dichloromethane / 1 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C
3.1: N-chloro-succinimide / acetonitrile / 2 h / 20 °C / Inert atmosphere
4.1: acetonitrile / 20 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 40 °C
6.1: chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / tetrahydrofuran / 2.5 h / 100 °C / Inert atmosphere; Microwave irradiation
With
N-chloro-succinimide; thionyl chloride; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; tetrabutyl ammonium fluoride; sodium hydride; sodium t-butanolate;
In
tetrahydrofuran; dichloromethane; acetonitrile;
6.1: Buchwald reaction;
DOI:10.1016/j.tet.2012.06.072
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / dichloromethane / 1 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C
2.1: N-chloro-succinimide / acetonitrile / 2 h / 20 °C / Inert atmosphere
3.1: acetonitrile / 20 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 40 °C
5.1: chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / tetrahydrofuran / 2.5 h / 100 °C / Inert atmosphere; Microwave irradiation
With
N-chloro-succinimide; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; tetrabutyl ammonium fluoride; sodium hydride; sodium t-butanolate;
In
tetrahydrofuran; dichloromethane; acetonitrile;
5.1: Buchwald reaction;
DOI:10.1016/j.tet.2012.06.072
