[2-(tert-butyl-diphenyl-silanyloxy)-1-carbamoyl-2-phenyl-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[2-(tert-butyl-diphenyl-silanyloxy)-1-carbamoyl-2-phenyl-ethyl]-carbamic acid tert-butyl ester
CAS No.:273934-43-3
Molecular Formula:C₃₀H₃₈N₂O₄Si
Molecular Weight:518.728
Hs Code.:

[2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-1-carbamoyl-2-phenyl-ethyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[2-(tert-butyl-diphenyl-silanyloxy)-1-carbamoyl-2-phenyl-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of [2-(tert-butyl-diphenyl-silanyloxy)-1-carbamoyl-2-phenyl-ethyl]-carbamic acid tert-butyl ester

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Technology Process of [2-(tert-butyl-diphenyl-silanyloxy)-1-carbamoyl-2-phenyl-ethyl]-carbamic acid tert-butyl ester

There total 6 articles about [2-(tert-butyl-diphenyl-silanyloxy)-1-carbamoyl-2-phenyl-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 273934-42-2
2-tert-butoxycarbonylamino-3-(tert-butyl-diphenyl-silanyloxy)-3-phenyl-propionic acid

: 273934-43-3
[2-(tert-butyl-diphenyl-silanyloxy)-1-carbamoyl-2-phenyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: 2-tert-butoxycarbonylamino-3-(tert-butyl-diphenyl-silanyloxy)-3-phenyl-propionic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.25h;

With ammonium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.25h;

Reference yield:

: 102308-32-7
(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 273934-43-3
[2-(tert-butyl-diphenyl-silanyloxy)-1-carbamoyl-2-phenyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether / 1 h / 0 °C

2.1: 100 percent / imidazole / CHCl₃ / 0 - 20 °C

3.1: trifluoroacetic acid / CHCl₃ / 1 h / 20 °C

4.1: 92 percent / acetone / 2 h / 0 °C / Jones reagent

5.1: ClCOOEt; Et₃N / tetrahydrofuran / 0.25 h / 0 °C

5.2: 77 percent / aq. NH₃ / tetrahydrofuran / 0.25 h / 0 °C

With 1H-imidazole; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; chloroform; acetone; 1.1: Grignard reaction / 2.1: Substitution / 3.1: Substitution / 4.1: Oxidation / 5.1: Acylation / 5.2: Substitution;

Reference yield:

: 95715-86-9,108149-60-6
(S)-2,2-dimethyl-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester

: 273934-43-3
[2-(tert-butyl-diphenyl-silanyloxy)-1-carbamoyl-2-phenyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: DIBAL-H / toluene / 0.75 h / -78 °C

2.1: diethyl ether / 1 h / 0 °C

3.1: 100 percent / imidazole / CHCl₃ / 0 - 20 °C

4.1: trifluoroacetic acid / CHCl₃ / 1 h / 20 °C

5.1: 92 percent / acetone / 2 h / 0 °C / Jones reagent

6.1: ClCOOEt; Et₃N / tetrahydrofuran / 0.25 h / 0 °C

6.2: 77 percent / aq. NH₃ / tetrahydrofuran / 0.25 h / 0 °C

With 1H-imidazole; chloroformic acid ethyl ester; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; chloroform; acetone; toluene; 1.1: Reduction / 2.1: Grignard reaction / 3.1: Substitution / 4.1: Substitution / 5.1: Oxidation / 6.1: Acylation / 6.2: Substitution;