(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propylamine

Base Information

Chemical Name:(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propylamine
CAS No.:105281-31-0
Molecular Formula:C₁₆H₂₅NO₃
Molecular Weight:279.379
Hs Code.:

Synonyms:(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propylamine

Suppliers and Price of (R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propylamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propylamine

There total 6 articles about (R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105281-24-1,105369-31-1
<4S-<4α,4(S^*),5β>>-2,2-dimethyl-α-ethenyl-5-<(phenylmethoxy)methyl>-1,3-dioxolane-4-methanamine

: 105281-31-0
(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 18h; under 2280 - 3040 Torr;
DOI:10.1021/jo00375a057

Reference yield:

: 81028-12-8
(4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde

: 105281-31-0
(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) THF, RT, 2 h

2: 85 percent / DIBAL / toluene / 0.5 h

3: 1.) NaH / 1.) Et₂O, RT, 15 min, 2.) Et₂O, from -15 deg C to RT, 30 min

4: xylene / 48 h / Heating

5: 82 percent / 1 N aq. KOH / tetrahydrofuran / 4 h / 60 °C

6: 1.3 g / H₂ / 10percent Pd/C / ethanol / 18 h / 2280 - 3040 Torr

With potassium hydroxide; hydrogen; sodium hydride; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; toluene; xylene;
DOI:10.1021/jo00375a057

Reference yield:

: 90661-39-5
(E)-ethyl 3-((4S,5S)-5-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate

: 105281-31-0
(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / DIBAL / toluene / 0.5 h

2: 1.) NaH / 1.) Et₂O, RT, 15 min, 2.) Et₂O, from -15 deg C to RT, 30 min

3: xylene / 48 h / Heating

4: 82 percent / 1 N aq. KOH / tetrahydrofuran / 4 h / 60 °C

5: 1.3 g / H₂ / 10percent Pd/C / ethanol / 18 h / 2280 - 3040 Torr

With potassium hydroxide; hydrogen; sodium hydride; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; toluene; xylene;
DOI:10.1021/jo00375a057