tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-2-{[cyclopentyl(methyl)amino]carbonyl}-1-hydrazinecarboxylate

Base Information

Chemical Name:tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-2-{[cyclopentyl(methyl)amino]carbonyl}-1-hydrazinecarboxylate
CAS No.:738615-62-8
Molecular Formula:C₂₂H₃₄N₄O₄
Molecular Weight:418.536
Hs Code.:

Synonyms:tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-2-{[cyclopentyl(methyl)amino]carbonyl}-1-hydrazinecarboxylate

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Chemical Property of tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-2-{[cyclopentyl(methyl)amino]carbonyl}-1-hydrazinecarboxylate

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Technology Process of tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-2-{[cyclopentyl(methyl)amino]carbonyl}-1-hydrazinecarboxylate

There total 7 articles about tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-2-{[cyclopentyl(methyl)amino]carbonyl}-1-hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 2439-56-7
N-methylcyclopentylamine

: 32315-10-9
bis(trichloromethyl) carbonate

: 583845-15-2
tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-1-hydrazine carboxylate

: 738615-62-8
tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-2-{[cyclopentyl(methyl)amino]carbonyl}-1-hydrazinecarboxylate

Guidance literature:: bis(trichloromethyl) carbonate; tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-1-hydrazine carboxylate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

N-methylcyclopentylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 66739-89-7
4-(1,3-dioxolan-2-yl)benzonitrile

: 738615-62-8
tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-2-{[cyclopentyl(methyl)amino]carbonyl}-1-hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: LiAlH₄ / tetrahydrofuran

2.1: 98 percent / ethanol / 5 h / Heating

3.1: 98 percent / H₂ / 10 percent Pd/C / methanol

4.1: diisopropylethylamine / CH₂Cl₂ / 0.5 h / 20 °C

4.2: 46 percent / CH₂Cl₂ / 1 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 738615-62-8
tert-butyl 2-{4-[(acetylamino)methyl]benzyl}-2-{[cyclopentyl(methyl)amino]carbonyl}-1-hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: p-TsOH / toluene

2.1: LiAlH₄ / tetrahydrofuran

3.1: 98 percent / ethanol / 5 h / Heating

4.1: 98 percent / H₂ / 10 percent Pd/C / methanol

5.1: diisopropylethylamine / CH₂Cl₂ / 0.5 h / 20 °C

5.2: 46 percent / CH₂Cl₂ / 1 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;