N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)-2-fluorobenzamide

Base Information

Chemical Name:N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)-2-fluorobenzamide
CAS No.:1373938-69-2
Molecular Formula:C₂₃H₁₉FN₄O₃
Molecular Weight:418.427
Hs Code.:

Synonyms:N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)-2-fluorobenzamide

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Chemical Property of N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)-2-fluorobenzamide

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Technology Process of N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)-2-fluorobenzamide

There total 6 articles about N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)-2-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1373940-39-6
N-(5-bromopyrazin-2-yl)-2-fluorobenzamide

: 1373939-82-2
5,5-dimethyl-3-(4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl) isoxazol-4(5H)-one

: 1373938-69-2
N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)-2-fluorobenzamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; for 24h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c01403

Reference yield:

: 1373939-84-4
1-(3-bromo-4-methylphenyl)-3-methylbut-2-en-1-one

: 1373938-69-2
N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C

2: pyridine; hydroxylamine hydrochloride / methanol / 12 h / Reflux

3: acetic acid; chromium(VI) oxide; sulfuric acid / water / 0.5 h / 100 °C

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

5: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 24 h / 100 °C / Inert atmosphere

With pyridine; chromium(VI) oxide; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; hydroxylamine hydrochloride; potassium acetate; sodium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/acs.jmedchem.1c01403

Reference yield:

: 1373939-85-5
(3-bromo-4-methylphenyl)(3,3-dimethyloxiran-2-yl)methanone

: 1373938-69-2
N-(5-(5-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; hydroxylamine hydrochloride / methanol / 12 h / Reflux

2: acetic acid; chromium(VI) oxide; sulfuric acid / water / 0.5 h / 100 °C

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

4: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 24 h / 100 °C / Inert atmosphere

With pyridine; chromium(VI) oxide; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; hydroxylamine hydrochloride; potassium acetate; sodium carbonate; acetic acid; In 1,4-dioxane; methanol; water;
DOI:10.1021/acs.jmedchem.1c01403