trans-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}-N-(imidazol[1,2-a]pyridin-8-ylmethyl)cyclobutanamine

Base Information

• Chemical Name: trans-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}-N-(imidazol[1,2-a]pyridin-8-ylmethyl)cyclobutanamine
• CAS No.: 1402911-24-3
• Molecular Formula: C₂₂H₂₅F₂N₃O
• Molecular Weight: 385.457
• Mol file: 1402911-24-3.mol

Synonyms:trans-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}-N-(imidazol[1,2-a]pyridin-8-ylmethyl)cyclobutanamine

Chemical Property of trans-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}-N-(imidazol[1,2-a]pyridin-8-ylmethyl)cyclobutanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}-N-(imidazol[1,2-a]pyridin-8-ylmethyl)cyclobutanamine

There total 3 articles about trans-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}-N-(imidazol[1,2-a]pyridin-8-ylmethyl)cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}cyclobutanamine + 8-imidazo<1,2-a>pyridinecarboxaldehyde (136117-74-3) → trans-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}-N-(imidazol[1,2-a]pyridin-8-ylmethyl)cyclobutanamine (1402911-24-3)

Guidance literature:

trans-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}cyclobutanamine; 8-imidazo<1,2-a>pyridinecarboxaldehyde; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

4-(tert-butyl)-3,5-difluorophenol (910486-78-1) → trans-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}-N-(imidazol[1,2-a]pyridin-8-ylmethyl)cyclobutanamine (1402911-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 23.5 h / 45 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

3.2: 20 °C / Inert atmosphere

With hydrogenchloride; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

1,1-dimethylethyl (trans-3-((4-(1,1-dimethylethyl)-3,5-difluorophenyl)oxy)cyclobutyl)carbamate → trans-3-{[4-(1,1-dimethylethyl)-3,5-difluorophenyl]oxy}-N-(imidazol[1,2-a]pyridin-8-ylmethyl)cyclobutanamine (1402911-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

2.2: 20 °C / Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

upstream raw materials:

4-(tert-butyl)-3,5-difluorophenol

8-imidazo<1,2-a>pyridinecarboxaldehyde