(5'-(difluoromethyl)-2-(2,2-dimethylcyclopentyl)-2'-fluoro-1,1'-biphenyl-4-yl)methanol

Base Information

Chemical Name:(5'-(difluoromethyl)-2-(2,2-dimethylcyclopentyl)-2'-fluoro-1,1'-biphenyl-4-yl)methanol
CAS No.:1142228-35-0
Molecular Formula:C₂₁H₂₃F₃O
Molecular Weight:348.408
Hs Code.:

Synonyms:(5'-(difluoromethyl)-2-(2,2-dimethylcyclopentyl)-2'-fluoro-1,1'-biphenyl-4-yl)methanol

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Chemical Property of (5'-(difluoromethyl)-2-(2,2-dimethylcyclopentyl)-2'-fluoro-1,1'-biphenyl-4-yl)methanol

Chemical Property:

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Technology Process of (5'-(difluoromethyl)-2-(2,2-dimethylcyclopentyl)-2'-fluoro-1,1'-biphenyl-4-yl)methanol

There total 13 articles about (5'-(difluoromethyl)-2-(2,2-dimethylcyclopentyl)-2'-fluoro-1,1'-biphenyl-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1142228-34-9
methyl 5'-(difluoromethyl)-2-(2,2-dimethylcyclopentyl)-2'-fluoro-1,1'-biphenyl-4-carboxylate

: 1142228-35-0
(5'-(difluoromethyl)-2-(2,2-dimethylcyclopentyl)-2'-fluoro-1,1'-biphenyl-4-yl)methanol

Guidance literature:: methyl 5'-(difluoromethyl)-2-(2,2-dimethylcyclopentyl)-2'-fluoro-1,1'-biphenyl-4-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

With sodium hydroxide; In tetrahydrofuran;

Reference yield:

: 1011531-89-7
2-(5,5-dimethylcyclopent-1-en-1-yl)-4,4,5,5-tetramethyl-1 ,3 ,2-dioxaborolane

: 1142228-35-0
(5'-(difluoromethyl)-2-(2,2-dimethylcyclopentyl)-2'-fluoro-1,1'-biphenyl-4-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 21 h / 75 °C / Inert atmosphere

2.1: pyridinium p-toluenesulfonate / methanol / 19 h / 50 °C

3.1: dmap; triethylamine / dichloromethane / 0.33 h

3.2: 3 h / 20 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 19 h / 23 - 90 °C / Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 22.5 h / 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

With dmap; potassium phosphate; lithium aluminium tetrahydride; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 4541-32-6
2,2-dimethylcyclopentanone

: 1142228-35-0
(5'-(difluoromethyl)-2-(2,2-dimethylcyclopentyl)-2'-fluoro-1,1'-biphenyl-4-yl)methanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / -78 °C

1.2: 18 h / -78 - 20 °C

2.1: potassium phenolate / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / toluene / 2 h / 50 °C / Inert atmosphere

3.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 21 h / 75 °C / Inert atmosphere

4.1: pyridinium p-toluenesulfonate / methanol / 19 h / 50 °C

5.1: dmap; triethylamine / dichloromethane / 0.33 h

5.2: 3 h / 20 °C

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 19 h / 23 - 90 °C / Inert atmosphere

7.1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 22.5 h / 20 °C

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

With dmap; potassium phosphate; lithium aluminium tetrahydride; potassium phenolate; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; n-heptane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;