C₄₇H₅₂N₈O₆

Base Information

• Chemical Name: C₄₇H₅₂N₈O₆
• CAS No.: 1369595-13-0
• Molecular Formula: C₄₇H₅₂N₈O₆
• Molecular Weight: 824.98
• Mol file: 1369595-13-0.mol

Synonyms:C₄₇H₅₂N₈O₆

Chemical Property of C₄₇H₅₂N₈O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₇H₅₂N₈O₆

There total 11 articles about C₄₇H₅₂N₈O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C41H46BN5O6 + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → C47H52N8O6 (1369595-13-0)

Guidance literature:

With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 95 ℃; for 12h; Inert atmosphere;

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → C47H52N8O6 (1369595-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; sodium hydroxide / water / 0 - 20 °C

2: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 95 °C / Inert atmosphere

With sodium carbonate; potassium carbonate; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water;

Reference yield:

(S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester (1007882-59-8) + C35H34ClN5O4 (1369595-12-9) → C47H52N8O6 (1369595-13-0)

Guidance literature:

C₃₅H₃₄ClN₅O₄; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; bis(pinacol)diborane; In 1,4-dioxane; at 110 ℃;

(S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In tetrahydrofuran; at 90 ℃;

DOI:10.1016/j.bmcl.2016.06.063

upstream raw materials:

N-methoxycarbonyl-L-valine

L-valine

C₃₃H₃₁ClN₄O₃

(S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester