(4-Methoxy-benzyl)-[(E)-(1S,7S)-7-(4-methoxy-benzyloxy)-9-oxo-1-phenyl-non-3-enyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:(4-Methoxy-benzyl)-[(E)-(1S,7S)-7-(4-methoxy-benzyloxy)-9-oxo-1-phenyl-non-3-enyl]-carbamic acid 2-trimethylsilanyl-ethyl ester
CAS No.:124944-50-9
Molecular Formula:C₃₇H₄₉NO₆Si
Molecular Weight:631.885
Hs Code.:

Synonyms:(4-Methoxy-benzyl)-[(E)-(1S,7S)-7-(4-methoxy-benzyloxy)-9-oxo-1-phenyl-non-3-enyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of (4-Methoxy-benzyl)-[(E)-(1S,7S)-7-(4-methoxy-benzyloxy)-9-oxo-1-phenyl-non-3-enyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of (4-Methoxy-benzyl)-[(E)-(1S,7S)-7-(4-methoxy-benzyloxy)-9-oxo-1-phenyl-non-3-enyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

There total 21 articles about (4-Methoxy-benzyl)-[(E)-(1S,7S)-7-(4-methoxy-benzyloxy)-9-oxo-1-phenyl-non-3-enyl]-carbamic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 143371-34-0
[(E)-(1S,7S)-8-[1,3]Dithian-2-yl-7-(4-methoxy-benzyloxy)-1-phenyl-oct-3-enyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

: 124944-50-9
(4-Methoxy-benzyl)-[(E)-(1S,7S)-7-(4-methoxy-benzyloxy)-9-oxo-1-phenyl-non-3-enyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With water; methyl iodide; In acetonitrile; Ambient temperature;
DOI:10.1021/ja00047a008

Reference yield:

: 124944-47-4
{(S)-3-[(4-Methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-3-phenyl-propyl}-triphenyl-phosphonium; iodide

: 124944-50-9
(4-Methoxy-benzyl)-[(E)-(1S,7S)-7-(4-methoxy-benzyloxy)-9-oxo-1-phenyl-non-3-enyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: n-butyllithium, LiBr / tetrahydrofuran / 0.75 h / 0 °C

2: 2.) phenyllithium, 3.) t-BuOK

3: 96 percent / CH₃COOH, H₂O / tetrahydrofuran / 1 h / Ambient temperature

4: 80 percent / pyridine / 48 h / Ambient temperature

5: 97 percent / NaH, 18-crown-6 / tetrahydrofuran / 3 h

6: 1.) n-butyllithium / 1.) THF, hexane, -23 deg C, 80 min, 2.) THF, hexane, 5 min

7: 1.) KH, 2.) tetrabutylammonium chloride, 18-crown-6 / 1.) THF, 15 min, 2.) THF, RT, 20 min

8: 86 percent / sodium naphthalenide / 1,2-dimethoxy-ethane / 0.67 h / -78 °C

9: 99 percent / K₂CO₃ / tetrahydrofuran; toluene

10: 85 percent / MeI, H₂O / acetonitrile / Ambient temperature

With pyridine; n-butyllithium; 18-crown-6 ether; potassium tert-butylate; tetrabutyl-ammonium chloride; water; potassium hydride; sodium naphthalenide; sodium hydride; potassium carbonate; acetic acid; phenyllithium; lithium bromide; methyl iodide; In tetrahydrofuran; 1,2-dimethoxyethane; toluene; acetonitrile;
DOI:10.1021/ja00047a008

Reference yield:

: N-(4-Methoxy-benzyl)-4-methyl-N-[(S)-1-phenyl-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-benzenesulfonamide

: 124944-50-9
(4-Methoxy-benzyl)-[(E)-(1S,7S)-7-(4-methoxy-benzyloxy)-9-oxo-1-phenyl-non-3-enyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 2.) phenyllithium, 3.) t-BuOK

2: 96 percent / CH₃COOH, H₂O / tetrahydrofuran / 1 h / Ambient temperature

3: 80 percent / pyridine / 48 h / Ambient temperature

4: 97 percent / NaH, 18-crown-6 / tetrahydrofuran / 3 h

5: 1.) n-butyllithium / 1.) THF, hexane, -23 deg C, 80 min, 2.) THF, hexane, 5 min

6: 1.) KH, 2.) tetrabutylammonium chloride, 18-crown-6 / 1.) THF, 15 min, 2.) THF, RT, 20 min

7: 86 percent / sodium naphthalenide / 1,2-dimethoxy-ethane / 0.67 h / -78 °C

8: 99 percent / K₂CO₃ / tetrahydrofuran; toluene

9: 85 percent / MeI, H₂O / acetonitrile / Ambient temperature

With pyridine; n-butyllithium; 18-crown-6 ether; potassium tert-butylate; tetrabutyl-ammonium chloride; water; potassium hydride; sodium naphthalenide; sodium hydride; potassium carbonate; acetic acid; phenyllithium; methyl iodide; In tetrahydrofuran; 1,2-dimethoxyethane; toluene; acetonitrile;
DOI:10.1021/ja00047a008