C₂₂H₂₈O₃

Base Information

• Chemical Name: C₂₂H₂₈O₃
• CAS No.: 954097-11-1
• Molecular Formula: C₂₂H₂₈O₃
• Molecular Weight: 340.463
• Mol file: 954097-11-1.mol

Synonyms:C₂₂H₂₈O₃

Chemical Property of C₂₂H₂₈O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₈O₃

There total 1 articles about C₂₂H₂₈O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

p-Methoxybenzyl bromide (2746-25-0) + (4S,6S)-4-Hydroxy-6-(benzyloxy)-1-heptene (136521-65-8) → C22H28O3 (954097-11-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 8h;

DOI:10.1016/j.tetlet.2007.07.184

Reference yield: 90.0%

C22H28O3 (954097-11-1) + 1-Heptyne (628-71-7) → C28H38O4 (954097-12-2)

Guidance literature:

C₂₂H₂₈O₃; With osmium(VIII) oxide; N-methyl-2-indolinone; water; In acetone; at 20 ℃; for 8h;

With sodium periodate; In dichloromethane; at 20 ℃; for 2h;

1-Heptyne; With n-butyllithium; In tetrahydrofuran; at -78 ℃; Further stages.;

DOI:10.1016/j.tetlet.2007.07.184

Reference yield:

C22H28O3 (954097-11-1) → C27H37NO2 (954097-09-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: OsO₄; NMO; water / acetone / 8 h / 20 °C

1.2: NaIO₄ / CH₂Cl₂ / 2 h / 20 °C

1.3: 90 percent / n-BuLi / tetrahydrofuran / -78 °C

2.1: 90 percent / LAH / tetrahydrofuran / 0 - 20 °C

3.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 0 - 20 °C

4.1: 95 percent / DDQ / CH₂Cl₂; H₂O / 20 °C

5.1: Et₃N; MsCl; DMAP / CH₂Cl₂ / 2 h / -20 - 40 °C

6.1: CH₂Cl₂ / 3 h / 20 °C

With dmap; osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; water; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; acetone; 6.1: double aza-Michael reaction;

DOI:10.1016/j.tetlet.2007.07.184

upstream raw materials:

p-Methoxybenzyl bromide

(4S,6S)-4-Hydroxy-6-(benzyloxy)-1-heptene

Downstream raw materials:

C₂₈H₃₈O₄

C₂₀H₂₈O₂

C₂₈H₄₀O₄

C₂₈H₃₈O₄