N-(4-(benzo[d]thiazol-2-yl)-3-methoxybenzyl)-5-(2-(2-(3-(tert-butyldimethylsilyloxy)phenyl)-4,4-dimethyl-4,5-dihydrofuran-3-yl)-2-methylpropoxy)pentanamide

Base Information

Chemical Name:N-(4-(benzo[d]thiazol-2-yl)-3-methoxybenzyl)-5-(2-(2-(3-(tert-butyldimethylsilyloxy)phenyl)-4,4-dimethyl-4,5-dihydrofuran-3-yl)-2-methylpropoxy)pentanamide
CAS No.:949913-11-5
Molecular Formula:C₄₂H₅₆N₂O₅SSi
Molecular Weight:729.069
Hs Code.:

N-(4-(benzo[d]thiazol-2-yl)-3-methoxybenzyl)-5-(2-(2-(3-(tert-butyldimethylsilyloxy)phenyl)-4,4-dimethyl-4,5-dihydrofuran-3-yl)-2-methylpropoxy)pentanamide

Synonyms:N-(4-(benzo[d]thiazol-2-yl)-3-methoxybenzyl)-5-(2-(2-(3-(tert-butyldimethylsilyloxy)phenyl)-4,4-dimethyl-4,5-dihydrofuran-3-yl)-2-methylpropoxy)pentanamide

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Chemical Property of N-(4-(benzo[d]thiazol-2-yl)-3-methoxybenzyl)-5-(2-(2-(3-(tert-butyldimethylsilyloxy)phenyl)-4,4-dimethyl-4,5-dihydrofuran-3-yl)-2-methylpropoxy)pentanamide

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Technology Process of N-(4-(benzo[d]thiazol-2-yl)-3-methoxybenzyl)-5-(2-(2-(3-(tert-butyldimethylsilyloxy)phenyl)-4,4-dimethyl-4,5-dihydrofuran-3-yl)-2-methylpropoxy)pentanamide

There total 3 articles about N-(4-(benzo[d]thiazol-2-yl)-3-methoxybenzyl)-5-(2-(2-(3-(tert-butyldimethylsilyloxy)phenyl)-4,4-dimethyl-4,5-dihydrofuran-3-yl)-2-methylpropoxy)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

: 949913-36-4
2-(4-aminomethyl-2-methoxyphenyl)benzothiazole

: 594859-93-5
5-(3-tert-butyldimethylsilyloxyphenyl)-4-(7-carboxy-1,1-dimethyl-3-oxaheptyl)-3,3-dimethyl-2,3-dihydrofuran N-hydroxysuccinimide ester

: 949913-11-5
N-(4-(benzo[d]thiazol-2-yl)-3-methoxybenzyl)-5-(2-(2-(3-(tert-butyldimethylsilyloxy)phenyl)-4,4-dimethyl-4,5-dihydrofuran-3-yl)-2-methylpropoxy)pentanamide

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.tet.2012.04.078

Reference yield:

: 594859-80-0
4-(7-carboxy-1,1-dimethyl-3-oxaheptyl )-5-(3-hydroxyphenyl)-3,3-dimethyl-2,3-dihydrofuran

: 949913-11-5
N-(4-(benzo[d]thiazol-2-yl)-3-methoxybenzyl)-5-(2-(2-(3-(tert-butyldimethylsilyloxy)phenyl)-4,4-dimethyl-4,5-dihydrofuran-3-yl)-2-methylpropoxy)pentanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: triethylamine / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.1: triethylamine / acetonitrile / 5 h / 20 °C / Inert atmosphere

With 1H-imidazole; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2012.04.078

Reference yield:

: 594859-92-4
5-(3-tert-butyldimethylsilyloxyphenyl)-4-(7-carboxy-1,1-dimethyl-3-oxaheptyl)-3,3-dimethyl-2,3-dihydrofuran

: 949913-11-5
N-(4-(benzo[d]thiazol-2-yl)-3-methoxybenzyl)-5-(2-(2-(3-(tert-butyldimethylsilyloxy)phenyl)-4,4-dimethyl-4,5-dihydrofuran-3-yl)-2-methylpropoxy)pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 1 h / 20 °C / Inert atmosphere

2: triethylamine / acetonitrile / 5 h / 20 °C / Inert atmosphere

With triethylamine; In acetonitrile;
DOI:10.1016/j.tet.2012.04.078