1-{[2-azido-5-(trifluoromethyl)phenyl]ethynyl}-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

Base Information

Chemical Name:1-{[2-azido-5-(trifluoromethyl)phenyl]ethynyl}-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one
CAS No.:1610967-53-7
Molecular Formula:C₁₆H₇F₃IN₃O₂
Molecular Weight:457.15
Hs Code.:

Synonyms:1-{[2-azido-5-(trifluoromethyl)phenyl]ethynyl}-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

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Chemical Property of 1-{[2-azido-5-(trifluoromethyl)phenyl]ethynyl}-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

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Technology Process of 1-{[2-azido-5-(trifluoromethyl)phenyl]ethynyl}-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

There total 1 articles about 1-{[2-azido-5-(trifluoromethyl)phenyl]ethynyl}-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 304-91-6
2-iodoxybenzoic acid

: 1610967-49-1
{[2-azido-5-(trifluoromethyl)phenyl]ethynyl}trimethylsilane

: 1610967-53-7
1-{[2-azido-5-(trifluoromethyl)phenyl]ethynyl}-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

Guidance literature:: 2-iodoxybenzoic acid; {[2-azido-5-(trifluoromethyl)phenyl]ethynyl}trimethylsilane; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

With pyridine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol5012604

Reference yield: 61.0%

: 1610967-53-7
1-{[2-azido-5-(trifluoromethyl)phenyl]ethynyl}-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

: 1610967-57-1
(Z)-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide

: 1610967-16-2
(Z)-N-{[2-azido-5-(trifluoromethyl)phenyl]ethynyl}-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide

Guidance literature:: With potassium phosphate; copper(l) iodide; In tetrahydrofuran; at 50 ℃; for 3h;
DOI:10.1021/ol5012604

Reference yield:

: 1610967-53-7
1-{[2-azido-5-(trifluoromethyl)phenyl]ethynyl}-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

: 1610967-57-1
(Z)-4-methyl-N-{2-[3-(trimethylsilyl)prop-1-en-1-yl]phenyl}benzenesulfonamide

: 1610967-22-0
5-tosyl-9-(trifluoromethyl)-11-vinyl-6,11-dihydro-5H-indolo[2,3-b]quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium phosphate / tetrahydrofuran / 3 h / 50 °C

2: C₂₁H₁₂AuClF₉P*CF₃O₃S^(1-)*Ag⁽¹⁺⁾ / nitromethane / 5 h / 20 °C

With potassium phosphate; copper(l) iodide; C₂₁H₁₂AuClF₉P*CF₃O₃S^(1-)*Ag⁽¹⁺⁾; In tetrahydrofuran; nitromethane;
DOI:10.1021/ol5012604