2-[1-(1-benzhydryl-azetidin-3-yl)-6-fluoro-1H-indazol-3-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

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Chemical Name:2-[1-(1-benzhydryl-azetidin-3-yl)-6-fluoro-1H-indazol-3-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid
CAS No.:1426422-31-2
Molecular Formula:C₃₆H₃₇FN₆O₃Si
Molecular Weight:648.812
Hs Code.:

Synonyms:2-[1-(1-benzhydryl-azetidin-3-yl)-6-fluoro-1H-indazol-3-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

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Chemical Property of 2-[1-(1-benzhydryl-azetidin-3-yl)-6-fluoro-1H-indazol-3-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

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Technology Process of 2-[1-(1-benzhydryl-azetidin-3-yl)-6-fluoro-1H-indazol-3-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

There total 12 articles about 2-[1-(1-benzhydryl-azetidin-3-yl)-6-fluoro-1H-indazol-3-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1426422-30-1
2-[1-(1-benzhydryl-azetidin-3-yl)-6-fluoro-1H-indazol-3-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

: 1426422-31-2
2-[1-(1-benzhydryl-azetidin-3-yl)-6-fluoro-1H-indazol-3-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

Guidance literature:: With sodium chlorite; potassium dihydrogenphosphate; aminosulfonic acid; In 1,4-dioxane; water; at 0 - 20 ℃;

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1426422-31-2
2-[1-(1-benzhydryl-azetidin-3-yl)-6-fluoro-1H-indazol-3-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 0 - 20 °C

2.1: chloroform / 8 h / Reflux; Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C / Microwave irradiation; Sealed tube

5.1: aminosulfonic acid; sodium chlorite; potassium dihydrogenphosphate / 1,4-dioxane; water / 0 - 20 °C

With sodium chlorite; potassium dihydrogenphosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aminosulfonic acid; sodium hydride; caesium carbonate; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1334674-87-1
(2-bromo-5-hydroxymethyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol

: 1426422-31-2
2-[1-(1-benzhydryl-azetidin-3-yl)-6-fluoro-1H-indazol-3-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / tetrahydrofuran

2.1: Jones reagent / acetone / 0.25 h

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 0 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C / Microwave irradiation; Sealed tube

6.1: aminosulfonic acid; sodium chlorite; potassium dihydrogenphosphate / 1,4-dioxane; water / 0 - 20 °C

With sodium chlorite; potassium dihydrogenphosphate; copper(l) iodide; Jones reagent; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aminosulfonic acid; water; sodium hydride; caesium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; mineral oil;