Technology Process of tert-butyl 1-(4-(5-(4-ethyl-5-(pyridin-2-yl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate
There total 12 articles about tert-butyl 1-(4-(5-(4-ethyl-5-(pyridin-2-yl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
at 80 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide; trifluoroacetic acid / 0.5 h / 150 °C / Microwave irradiation
2: bis-triphenylphosphine-palladium(II) chloride; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate / 1,4-dioxane / 2 h / 170 °C / Microwave irradiation
3: hydrogen / palladium on activated charcoal / ethanol / 5 h / 2327.23 Torr
4: water; sodium hydroxide / methanol / 0.33 h / 80 °C
5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 80 °C
With
N-Bromosuccinimide; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate;
In
1,4-dioxane; methanol; ethanol; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: bis-triphenylphosphine-palladium(II) chloride; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate / 1,4-dioxane / 2 h / 170 °C / Microwave irradiation
2: hydrogen / palladium on activated charcoal / ethanol / 5 h / 2327.23 Torr
3: water; sodium hydroxide / methanol / 0.33 h / 80 °C
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 80 °C
With
water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate;
In
1,4-dioxane; methanol; ethanol; acetonitrile;
