(S)-2-phenyl-1-tosylazetidine

Base Information

Chemical Name:(S)-2-phenyl-1-tosylazetidine
CAS No.:936011-91-5
Molecular Formula:C₁₆H₁₇NO₂S
Molecular Weight:287.382
Hs Code.:

Synonyms:(S)-2-phenyl-1-tosylazetidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-phenyl-1-tosylazetidine

Chemical Property:

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Technology Process of (S)-2-phenyl-1-tosylazetidine

There total 15 articles about (S)-2-phenyl-1-tosylazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 143371-09-9
(S)-N-(3-hydroxy-1-phenylpropyl)-4-methylbenzenesulfonamide

: 936011-91-5
(S)-2-phenyl-1-tosylazetidine

Guidance literature:: With potassium hydroxide; p-toluenesulfonyl chloride; In tetrahydrofuran; for 0.5h; Heating;
DOI:10.1016/j.tetlet.2007.02.033

Reference yield:

: 936012-06-5
C₁₆H₁₇NO₄S

: 1079366-88-3
(R)-2-phenyl-1-(toluene-4-sulfonyl)azetidine

: 936011-91-5
(S)-2-phenyl-1-tosylazetidine

Guidance literature:: With p-toluenesulfonyl chloride; potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.75h; Overall yield = 75 %; Overall yield = 70 mg; Reflux;
DOI:10.1039/c5ob01140j

Reference yield:

: 875-74-1
(R)-phenylglycine

: 936011-91-5
(S)-2-phenyl-1-tosylazetidine

Guidance literature:: Multi-step reaction with 6 steps

1: NaBH₄; I₂ / tetrahydrofuran / 18 h

2: pyridine / -30 - 0 °C

3: dimethylsulfoxide / 2 h / 20 °C

4: 85 percent / DIBAL-H / tetrahydrofuran / 0.5 h / -65 °C

5: 90 percent / NaBH₄ / methanol / 2 h / 0 - 20 °C

6: 98 percent / TsCl; KOH / tetrahydrofuran / 0.5 h / Heating

With pyridine; potassium hydroxide; sodium tetrahydroborate; iodine; diisobutylaluminium hydride; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2007.02.033