2-(2,2-Dimethylpropyl)benzaldehyde

Base Information

• Chemical Name: 2-(2,2-Dimethylpropyl)benzaldehyde
• CAS No.: 155876-95-2
• Molecular Formula: C₁₂H₁₆O
• Molecular Weight: 176.258
• Mol file: 155876-95-2.mol

Synonyms:2-(2,2-Dimethylpropyl)benzaldehyde

Chemical Property of 2-(2,2-Dimethylpropyl)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,2-Dimethylpropyl)benzaldehyde

There total 6 articles about 2-(2,2-Dimethylpropyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-(2,2-Dimethylpropyl)benzyl alcohol (51351-80-5) → 2-(2,2-Dimethylpropyl)benzaldehyde (155876-95-2)

Guidance literature:

With chromium trioxide-pyridine complex; In diethyl ether; acetic acid; at 5 ℃; for 0.25h;

DOI:10.1021/jo00093a014

Reference yield:

C19H23N2O3S(1-)*Na(1+) → 1,3-dihydroisobenzofuran (496-14-0) + 1-tert-butyl-1,3-dihydro-isobenzofuran (54537-66-5) + 7-tert-Butoxy-bicyclo[4.2.0]octa-1(6),2,4-triene + 2-(2,2-Dimethylpropyl)benzaldehyde (155876-95-2)

Guidance literature:

at 280 - 300 ℃;

DOI:10.1016/0040-4039(94)88323-8

Reference yield:

3-(tert-butyl)-1(3H)-isobenzofuranone (54537-68-7) → 2-(2,2-Dimethylpropyl)benzaldehyde (155876-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) aq. NaOH, 2.) H₂, sodium hydrogen phosphate, H₃PO₄ / 2.) 10percent Pd/C / 1.) 95 deg C, 45 min, 2.) 120 deg C, 2.8 atm, 14 h

2: 86 percent / LiAlH₄ / diethyl ether / 5 h / Heating

3: 81 percent / CrO₃-pyridine / acetic acid; diethyl ether / 0.25 h / 5 °C

With sodium hydroxide; disodium hydrogenphosphate; lithium aluminium tetrahydride; phosphoric acid; chromium trioxide-pyridine complex; hydrogen; palladium on activated charcoal; In diethyl ether; acetic acid;

DOI:10.1021/jo00093a014

upstream raw materials:

2-(2,2-Dimethylpropyl)benzyl alcohol

<2-(2,2-Dimethylpropyl)phenyl>diazomethane

3-(tert-butyl)-1(3H)-isobenzofuranone

2-(2,2-Dimethylpropyl)benzoic acid

Downstream raw materials:

2-(2,2-Dimethylpropyl)benzaldehyde tosylhydrazone

<2-(2,2-Dimethylpropyl)phenyl>diazomethane