3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanamide

Base Information

Chemical Name:3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanamide
CAS No.:1069046-30-5
Molecular Formula:C₂₅H₂₄N₂O
Molecular Weight:368.478
Hs Code.:

Synonyms:3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanamide

Suppliers and Price of 3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanamide

There total 9 articles about 3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1069045-83-5
3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid

: 1069046-30-5
3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanamide

Guidance literature:: 3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

With ammonium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jm500494y

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1069046-30-5
3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper(I) bromide; potassium carbonate; potassium hydroxide; copper diacetate / 140 °C

2.1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C

2.2: 3 h / 20 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C / Cooling with ice

3.2: Cooling with ice

4.1: tin(IV) chloride; triethylsilane / dichloromethane / 1 h / -78 °C

5.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 5 h / 120 °C / Sealed tube

6.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating

6.2: pH 1

7.1: palladium on activated charcoal; hydrogen / methanol / 20 °C

8.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 4 h / 0 - 20 °C

8.2: 1 h / 20 °C

With triethylsilane; aluminum (III) chloride; sodium tetrahydroborate; palladium on activated charcoal; hydrogen; copper diacetate; palladium diacetate; tin(IV) chloride; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; 1,1'-carbonyldiimidazole; potassium hydroxide; copper(I) bromide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 2.1: |Friedel-Crafts Acylation / 2.2: |Friedel-Crafts Acylation / 5.1: |Heck Reaction;
DOI:10.1021/jm500494y

Reference yield:

: 504424-70-8
5-bromo-1-phenyl-1H-indole

: 1069046-30-5
3-[1-phenyl-3-(2-phenylethyl)-1H-indol-5-yl]propanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C

1.2: 3 h / 20 °C

2.1: sodium tetrahydroborate / methanol / 1 h / 20 °C / Cooling with ice

2.2: Cooling with ice

3.1: tin(IV) chloride; triethylsilane / dichloromethane / 1 h / -78 °C

4.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 5 h / 120 °C / Sealed tube

5.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating

5.2: pH 1

6.1: palladium on activated charcoal; hydrogen / methanol / 20 °C

7.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 4 h / 0 - 20 °C

7.2: 1 h / 20 °C

With triethylsilane; aluminum (III) chloride; sodium tetrahydroborate; palladium on activated charcoal; hydrogen; palladium diacetate; tin(IV) chloride; triethylamine; tris-(o-tolyl)phosphine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 1.1: |Friedel-Crafts Acylation / 1.2: |Friedel-Crafts Acylation / 4.1: |Heck Reaction;
DOI:10.1021/jm500494y